The learned Doctor FREIND in his History of Physic from the time of GALEN, has this remarkable passage: "By the earliest account we have of the Small Pox, we find it first appeared in _Ægypt_ in the time of _Omar_, successor to _Mahomet_: though no doubt, since the _Greeks_ knew nothing of it, the _Arabians_ brought it from their own country, and might derive it originally from some of the more distant regions of the _East_." The sagacity of this conclusion, later times and discoveries has fully verified; at the period in which the _Aughtorrah Bhade_ scriptures of the Gentoos were promulged, (according to the Bramins three thousand three hundred and sixty six years ago;) this disease must then have been of some standing, as those scriptures institute a form of divine worship, with _Poojahs_, or offerings, to a female Divinity, stiled by the common people _Gootee ka Tagooran_ (the Goddess of Spots,) whose aid and patronage are invoked during the continuance of the Small Pox season, also in the Measles, and every cutaneous Eruption that is in the smallest degree epidemical. Due weight being given to this circumstance, the long duration of the Disease in Indostan will manifestly appear; and we may add to the sagacious conjecture just quoted, that not only the _Arabians_, but the _Ægyptians_ also, by their early commerce with India through the Red Sea and Gulf of Mocha, most certainly derived originally the Small Pox (and probably the Measles likewise) from that country, where those diseases have reigned from the earliest known times. Inoculation is performed in Indostan by a particular tribe of Bramins, who are delegated annually for this service from the different Colleges of Bindoobund, Eleabas, Banaras, &c. over all the distant Provinces; dividing themselves into small parties, of three or four each, they plan their travelling circuits in such wise as to arrive at the places of their respective destination some weeks before the usual return of the disease; they arrive commonly in the Bengali Provinces early in February, although they some years do not begin to inoculate before March, deferring it until they consider the state of the season, and acquire information of the state of the distemper.