The internal Medicines they used were such as they deemed Alexipharmics. _Armenian_ Bole, Bezoar both animal and mineral, Pearls, and, according to the Philosophy of those Times, the precious Stones. The _Theriaca_ was excepted against for Children, as _Galen_ had condemned its Use in such young Subjects. But after they had lessened, as they thought, the Plethora by Bleeding, and the Cacochemy, as they stiled it, by a Cathartic; as they found, from Experience, that no Concoction of Humours was to be waited for in this Case[27], without laying much Stress upon Internals, they seem chiefly to have applied themselves to Topics; considering the Disease as local, and a peculiar morbid Affection of the _Fauces_. In this Part of their Directions they have been more particular; and some of them, in order to point out their Applications with more Propriety, have divided the Course of this Disease into four different Periods[28]. The first is the State of Inflammation. In this Repellents were thought necessary; such as Vinegar in Barley-water, Syrup of Roses, Mulberries, and Purslain. The second, is that wherein the white Sloughs begin to appear, which is a Step towards a gangrenous Colliquation. In this State they order'd mild Abstergents, of which Honey of Roses was esteemed the chief. In the third, the _Fauces_ begin to look black, and a real Mortification is come on, sometimes penetrating to a considerable Depth, with great Putrefaction. Here the mild Abstergents were deem'd ineffectual, and Caustics were recommended; such as Alum with Honey, Alum-Water, Oil of Sulphur, and Oil of Vitriol. These were used both to check the Putrefaction, and to destroy the mortified Flesh. Sometimes the Oil of Vitriol was dextrously applied to the Part affected by an arm'd Probe; but it was oftener mix'd with Syrup of Roses, and in Children pour'd into the Mouth. Bole dissolv'd in Treacle-Water, and the Juice of Wood-Sorrel, was used by some for the like Purposes. In the fourth Stage the Putrefaction is supposed to be extinguished, the mortified Parts cast off, and an Ulcer only remains. In this Case, the Fume of white Amber thrown on live Coals, and received into the Mouth, as a _Suffitus_, was advised; also the _Vinum Myrrhites_, a Decoction of Guaiacum, Roses, Balaustines, Pomegranate-Peels by way of Gargle; Medicines that were supposed to dry with some Degree of Astringency. Such was the general Appearance of this Disease at its first being taken notice of in _Europe_; and such, as far as I can collect, the Methods that were pursued in treating it, by the most eminent Practitioners at that time. The Disease which is described in the following Pages, seems to be the same with this _Angina maligna_, or strangulatory Affection of the _Fauces_, and seems only to differ from it in Degree; in which, as it is much more favourable and mild with us in general, than it was with them, we have greatly the Advantage.