A few{253} of Skoda's more eminent colleagues deserve brief mention: Oppolzer (1808-1871) was singularly gifted in diagnosis, popular, a teacher of wide influence, and manifested in superlative degree the characteristics that constitute a great physician; he wrote little, but was for a long time Professor of Medicine at Prague. Von Hebra, the elder (1816-1880), worked a complete revolution in dermatology, and developed a classification based upon the pathological anatomy of the skin. He instituted a new and independent line of therapeutics as applied to this branch of our art, for which the medical world will ever hold him in grateful remembrance. Sigmund and Zeissel during the same period did much to clear up the problems of syphilis. To Czermak (1828-1873) and TUrck (1807-1868) we are indebted (practically) for the making a specialty of diseases of the nose and larynx; of like service to ophthalmology were Jàger, Jaxtthal, Arlt, Stellwag von Carion, Hasner, Mauthner, Fuchs, and von Reuss, while Gruber and Politzer did as much for diseases of the ear. An indirect offshoot of the new Vienna school is the so-called "Physiological Medicine," founded by Eoser (1817-1888),{254} of Stuttgart (late Professor of Surgery in Marburg), seconded by Griesinger and Wunderlich. Their views were directed against the symptomatologists and idealists, and particularly against the School of Natural History, the claim being that physiology must include vital phenomena, while from the morbid portions of these phenomena the special science should be formed as an artificial, yet practical, division of knowledge. 'Wunderlich's book of therapeutics was for a long time the best guide in this direction, inasmuch as it left to individual thought and judgment--the Hippocratic method of investigation--the determination of value and demand. Another offshoot, that differs but little from this save in definition, is the "School of Rational Medicine," originated by Pfeufer (1806-1869) and Henle (1809-1855), and which, since 1841, has been represented by a special journal. While Wunderlich claimed pathology to be the physiology of the sick, Henle considered this questionable and made no distinction at all between the physiology of the healthy and that of the ill. The language of the followers of this school contrasted strongly with that emanating from other schools, and for a time was confident and ingeniously triumphant; nevertheless, it did not forget philosophical speculation, and Hegel may now be regarded as indirectly the godfather of rational medicine.