These likewise depend on the too great Cohesion of the sanguineous Particles, on which account the Circulatory as well as the Motion of the intestine Particles of the Blood being diminish'd, and many of the Igneous Particles intangled in the viscous Cohesions, a Sensation of Cold must necessarily ensue, and especially in those Parts where the Motion of the Blood is most slow, and its Cohesion increased as happens in the Extremities. The nervous Juice being likewise for the same reason determin'd Irregularly, and in less Quantity into the Muscles, sometimes one, sometimes another of them will be weakly contracted, or a Shuddering will ensue. [Sidenote: _A Low, quick, unequal Pulse._] These arise from the Secretion of a smaller Quantity of Animal Spirits, and those too unfit to actuate the Heart and other Muscles, whence their Contractions will be more weak, and being stimulated by the Acrimony of the Juices more frequent than in a Natural State. The Derivation likewise of the Nervous Fluid into the _Fibres_ of the Heart being irregular, for the Reasons afore-given, the Motion of the Heart, and consequently of the Pulse, must be weak, quick, and unequal. [Sidenote: _Loathing, Vomiting._] These are occasion'd partly by the Contagious Particles being drawn in with the Breath, and in their Passage tainting the _Saliva_, which when swallowed Irritates the Nervous Filaments of the Stomach, and partly by the Secretion of a more Pungent and Acrid Matter by its Glandulous Coat; as appears from their spontaneous Ceasing as soon as a Sweat can be procured, and the Discharge of these Acrid Particles promoted by the Perspirable Glands[u], and seldom otherwise. [u] _Sydenham_ de Peste. [Sidenote: _Diarrhoea._] A _Diarrhoea_ is likewise oftentimes a Concomitant of these Fevers, and ever of most dangerous Consequence in the Beginning of the Disease, inasmuch as it exhausts the Strength of the Patient, and prevents the regular Expulsion of the Perspirable Matter, by which Experience assures us that these Contagious Particles are most effectually discharg'd. These then indicate such Medicines as cleanse the _Primæ Viæ_ from the Contagious Particles, and other Crudities lodged in them, blunt the Acrimony of the Saline Particles, and promote the Regular Expulsion of the Perspirable Matter. [Sidenote: _Coldness of the Extremities._]