This Poison acts differently upon different Bodies, in Proportion to the Strength or Weakness of the Subject, the Time it has been taken, whether upon a full or empty Stomach, before or after plentiful Eating or Drinking; and indeed, through these Circumstances, the Power of it is so much varied, that they cannot be too particularly attended to. The Quantity taken should be known, as nearly as possible, if in a solid or liquid State, and whether the Party ever was habituated to the Use of this Drug. These Particulars are often difficult to be ascertained, owing either to the Ignorance or Fright of the Bystanders; and it rarely happens that the Patient is in a Condition to inform you himself; notwithstanding, Nature in this, as in many other Cases, indicates a Cure. She must first be assisted in disengaging herself from the Poison, by Vomit; though this, if the Stimulus should be very violent, will encrease, rather than diminish, the Inflammation of the Stomach; yet even an Excess in that Particular is better than to hazard the Opium remaining any Length of Time undisturbed, which would more endanger the Life of the Patient, unless of a very strong Constitution.——The Symptoms therefore, as before mentioned, alone can direct us, namely, whether in the first Degree they are similar to those of Ebriety, in the second and more violent, consisting of a heavy unnatural Stupor, &c. or third, and most extream, in Vertigoes, Convulsions, cold Sweats, &c. Doctor _Jones_ attributes the Sensations from, and indeed the whole Action of this Poison, to so close an Adhesion of the resinous Parts to the internal Coats of the Stomach, that though the Stimulus thereby occasions frequent Vomitings, they cannot be disengaged from it, but must necessarily be dissolved and digested, and therefore, where the Patient recovers, are carried off by Stool. Now, that the Poison cannot be attributed to the Resin it contains, as this Author asserts throughout his Treatise, appears to me manifest; for upon an Analysis, the Power of Action consists in a volatile Salt, minutely blended with a corrosive Oil; which being expanded over the whole Stomach, villicates and inflames the nervous Membrane thereof, communicating her Affects to the Brain, even to the Destruction of Life; unless overcome by Art.—Were it the Resin only which occasioned the Mischief, the Resin of any other Vegetable would probably perform the same; but a Person may take a Quantity of any common Resin, which is a vegetable Production from the Pine, without these violent and dangerous Effects, therefore we cannot advise, with Dr. _Jones_, the taking of highly sulphurous and rectified Spirits, in order to dissolve the Resin in the Stomach, lest, by such an additional Corrosiveness, the Stimulus and Contraction, instead of being diminished, should become more violent. Nor can I more approve his recommending the Use of Lixivial or Alkaline Salts, unless formed into a saponaceous Body, with Water and Oil.