Notwithstanding this conjectural Opinion of his, he again recommends Lixivial Salts and Spirit; and that their Use might not be neglected, tells you, if you should not have Salt of Tartar at hand, other Alkaline Salts will serve the Purpose; as of Wormwood, &c. but these being of a weaker Nature, their Quantity is to be encreased, at least, one third; and in great Urgency, from a Deficiency of them, their Ashes, or those of any Vegetable, may be taken; provided they are joined with Brandy, or old Wine; and that the Roughness of the Ashes will contribute not a little to wear off the Resin. _Geoffroy_ informs us, that the first Thing necessary to remedy this Poison, is to empty the Vessels by copious Bleeding, if Strength will admit. Though this is a Practice I do not condemn, yet, as not having experienced the Use, I cannot recommend it; for instead of relieving Nature thereby, I should fear a Relaxation might be hurried on, which ought to be prevented as much as possible.——In Fact, the Stomach is the Place of Action, and present Relief can only be obtained, rationally, by immediate Applications to that Part. The Effect of Opium upon the Venous Fluid, is not immediate, but secondary; for when injected into a Vein, it will neither encrease the Motion of the Blood, nor coagulate it. Sir _Christopher Wren_ gives us an Instance of this, by transfusing a Solution of Opium into the Blood of a Dog, which, he observed, had no Effect upon the Animal, until it had Time to reach his Brain, when the Dog became drowsy, and staggered; from which he was relieved, by being forced into Motion, and in a short Time afterwards grew fat. This, I think, proves, that the violent Effects of Opium are on the Nerves, and not upon the Blood, which, by a Consent of Parts, it can only rarify, and make more fluid. By diminishing the Quantity of Blood in the Veins, the Secretions of Sweat and Urine are interrupted, and the Relaxation, so much to be dreaded, is forwarded.——The great _Boyle_, and Dr. _Willis_, likewise mention Experiments of this Kind, made upon a Dog, but differ in their Accounts; _Willis_ asserting, that a Dog can bear a large Quantity of Opium, and overcome the Poison: He gives an Account of one that had received, by Transfusion, three Ounces of liquid Laudanum into his Veins, and without any very violent Symptoms, or other Help, than the Exercise of a Whip, to keep the Dog in Motion, he perfectly recovered. The Effect which followed Laudanum, being poured into a Dog's Stomach, as Dr. _Mead_ experimented, is very different from that by Transfusion, for it presently convulsed and killed him; and upon Dissection, he found that the Poison had not only inflamed the Coats of the Stomach, but abraded the finer Vessels of the Brain.