In the early records of Harvard University is a regulation ordering that "no scholar shall take tobacco unless permitted by the President, with the consent of his parents, on good reason first given by a physician, and then only in a sober and private manner." At a town-meeting in Portsmouth, N.H. in 1662, it was "ordered that a cage be built, or some other means devised, at the discretion of the Selectmen, to punish such as take tobacco on the Lord's day, in time of publick service." But it does not appear that this measure had all the effect intended, for, ten years afterwards, the town "voted that if any person shall smoke tobacco in the meeting-house during religious service, he shall pay a fine of five shillings for the use of the town." But all these forces have been vanquished, and this one weed is the conqueror. Regardless of collegial and town regulations, of provincial laws, and of royal, parliamentary and papal power, tobacco has kept on its way, till it has encircled the earth, and now holds in slavery a larger number of human minds than any other herb. _Effects of Tobacco upon Animal Life._ To the organs of smell and taste in their natural condition, it is one of the most disgusting and loathsome of all the products of the vegetable kingdom.[1] [Footnote 1: This is proved by applying it to these organs in infancy, among those children whose parents do not use tobacco. Caspar Hausser, who was fed wholly on farinaceous food and water, from infancy to the age of sixteen or seventeen years, was made sick to vomiting by walking for a "considerable time by the side of a tobacco field."] Dr. Franklin ascertained, that the oily material, which floats upon the surface of water, upon a stream of tobacco smoke being passed into it, is capable, when applied to the tongue of a cat, of destroying life in a few minutes. Mr. Brodie applied one drop of the empyreumatic oil of tobacco to the tongue of a cat; it occasioned immediate convulsions and an accelerated breathing. Five minutes after, the animal lay down on the side, and presented, from time to time, slight convulsive movements. A quarter of an hour after, it appeared recovered. The same quantity of the oil was applied again, and the animal died in two minutes. In December, 1833, aided by several gentlemen of the medical class, and occasionally in the presence of other individuals, I made a number of experiments upon cats and other animals, with the distilled oil of tobacco. EXPERIMENT 1. A small drop of the oil was rubbed upon the tongue of a large cat. Immediately the animal uttered piteous cries and began to froth at the mouth.