When applied to sensitive surfaces of considerable extent, even in a form somewhat dilute, tobacco often produces the most serious effects. The tea of tobacco has been known to destroy the life of a horse, when forced into his stomach to relieve indisposition. When used as a wash, to destroy vermin upon certain domestic animals, tobacco tea has been known to kill the animals themselves. A farmer not long since assured me, that he had destroyed a calf in this manner. "A woman applied to the heads of three children, for a disease of the scalp, an ointment prepared with the powder of tobacco and butter; soon after, they experienced dizziness, violent vomitings and faintings, accompanied with profuse sweats." [Orfila.] The celebrated French poet, Santeuil, came to his death through horrible pains and convulsions, from having taken a glass of wine, with which some snuff had been mixed. The tea of twenty or thirty grains of tobacco introduced into the human body, for the purpose of relieving spasm, has been known repeatedly to destroy life. The same tea, applied to parts affected with itch, has been followed by vomiting and convulsions. The same article, applied to the skin on the pit of the stomach, occasions faintness, vomiting, and cold sweats. I knew a young man, who, only from inhaling the vapor arising from the leaves of tobacco immersed in boiling water, was made alarmingly sick. A medical friend assured me that he was once thrown into a state of great prostration and nausea, from having a part of his hand moistened, for a few minutes, in a strong infusion of tobacco. Col. G. says, that during the late war, under hard service on the Canadian frontier, the soldiers not unfrequently disabled themselves for duty, by applying a moistened leaf of tobacco to the armpit. It caused great prostration and vomiting. Many were suddenly and violently seized soon after eating. On investigation, a tobacco leaf was found in the armpit. Dr. M. Long, of Warner, N. H., writes me, under date of April 26, 1834, that, on the 6th of May, 1825, he was consulted by Mrs. F. on account of her little daughter L. F., then five years old, who had a small ring-worm, scarcely three-fourths of an inch in diameter, situated upon the root of the nose. Her object was to ascertain the Doctor's opinion, as to the propriety of making a local application of tobacco in the case. He objected to it as an exceedingly hazardous measure; and, to impress his opinion more fully, related a case, a record of which he had seen, in which a father destroyed the life of his little son, by the use of tobacco spittle upon an eruption or humor of the head.