many instances of the disease being introduced into parishes, in which it did not before exist, by means of inoculation, the contagion afterwards spreading in all directions; and affirms (p. 272), that “thirty-eight surgeons, who from various motives, practised it, lost among those to whom they had thus given the disease, twenty-one patients; fourteen surgeons reported, that fifty-five deaths had been occasioned in the same way within their knowledge; and five other surgeons observed, that they had known several who fell a sacrifice to the practice.” It admits then of the most incontestable proof, and it is a fact, which cannot be too deeply impressed upon the minds of the public, that inoculation for Small Pox is a practice attended with very considerable danger to the individual who passes through it, while to society in general, it has been productive of the most pernicious consequences. Is it too much then to affirm, that it cannot be employed without great moral guilt being incurred both by those who may require its performance, and by the medical practitioner who shall be induced to practise it? But by far the most important mode in which Vaccination has been productive of the equally astonishing and gratifying consequences, which have been proved to have resulted from it, has been by its essential interference with the effect of the infectious matter of Small Pox, either by entirely preventing the occurrence of that disease, or by stripping it of all its dangerous and formidable characteristics—rendering it, in the comparatively few instances in which it has taken place at all after Vaccination, mild in its attack, and perfectly harmless in its consequences. It very generally happens, when a discovery is made which promises to exert any considerable influence over the happiness of man, that its capabilities cannot for some time be very accurately defined; and that the effects, which a few years’ experience shall prove it to possess the power of producing, will, at the commencement, be either undervalued or overrated. It would not, perhaps, be difficult to adduce instances of both. And it can scarcely excite surprise, that something like this should have been the case with incomparably the most important discovery of modern times, for such we may truly esteem Vaccination, whether we consider it as a means of preserving life, or of obviating effects, perhaps, even more deplorable than the loss of life itself.