It is true, that in some of the continental nations, where Vaccination has been most extensively and successfully employed, it has been made a matter of state policy, and legislative measures have been used to enforce its adoption; while, at home, it has rested with the public to adopt or reject it, as might be agreeable to their opinions or prejudices. Some writers have proposed that a similar mode of enforcing its general employment in England, by legislative compulsion, should be made use of; but, I conceive, such measures would be too little in accordance with the spirit of our government, and too repulsive to the feelings of Englishmen, to render them advisable, notwithstanding the paramount national importance of the object. That the time will presently arrive when this object will be fully accomplished, without any such unpalatable interference of the legislature, but by the irresistible force of truth alone, on the minds of the public, I cannot permit myself to doubt. Means of information on the subject, ample and satisfactory, are within the reach of all who are anxious to enquire; and it cannot be that they should long remain unexplored, or that they will fail to carry conviction to the mind of every candid and intelligent enquirer. But, when I reflect that the early conviction of a single individual, who entertains a doubt of the protective efficacy of Vaccination, or a prejudice against the practice, may be the direct or indirect means of saving the lives of many, I cannot refrain from most earnestly exhorting every one to consider this subject maturely—to be strenuous and unremitting in his enquiries respecting it, until every doubt is satisfied. He will then see one straight forward path of duty before him, which he will feel himself compelled, by every moral and religious obligation, most perseveringly and undeviatingly, to pursue. He will feel that his own personal exertions, in promoting the general use of Vaccination in his own family, amongst his dependents and all those whom he can in any the slightest degree influence, are essential to the accomplishment of the great philanthropic end proposed—the total extinction of Small Pox: a consummation that would prevent a larger portion of human misery, and preserve a larger number of human lives, than any other which it is in the power of imagination to conceive, or of reason to contemplate. ------------------------------------------------------------------------ TABLE I. The first column of this Table exhibits the total number of deaths, and the second column the number of deaths from Small Pox, occurring within the London Bills of Mortality, during every successive year, for a period of 121 years.