EXPERIMENT 12. "Burning right hind-foot caused a slight RISE IN BLOOD- PRESSURE. "Ten minims (drops) of chloroform on inhaler produced a DECIDED FALL in blood-pressure." EXPERIMENT 56. "Dog. Hind-foot burned, FOLLOWED BY A RISE IN BLOOD- PRESSURE.... Burning the nose caused A VERY MARKED RISE in blood-pressure. The animal, after the injection of cocaine, WAS NOT UNDER FULL ETHER ANAESTHESIA, CUNJUNCTIVAL REFLEX BEING PRESENT." EXPERIMENT 27. "Dog. Ether anaesthesia. Hind-foot was burned, producing A SHARP RISE in the blood-pressure. "Right paw again burned, and ARTERIAL PRESSURE ROSE.... Animal subjected to FURTHER BURNING, which was followed by ADDITIONAL SLIGHT RISE IN PRESSURE." A considerable number of experiments involved the adding of hot salt solution to the blood. EXPERIMENT 34. Dog, in good condition. Saline solution in jugular vein.... In this and in preceding experiments with the hot saline, the animal, THOUGH UNDER SURGICAL ANAESTHESIA, STRUGGLED. That shows the worth of the "surgical anaesthesia." When Professor Starling was asked how he might know that the anaesthesia was passing off, he told the Royal Commission that it was by noting the SLIGHT MOVEMNET of the the animal, IN CONJUNCTION WITH A RISE OF BLOOD- PRESSURE.[1] Scalding water in the blood seems to have given both of these signs: [1] Evidence before Royal Commission, Question 4,054. EXPERIMENT 11. At 3.35 saline at 64 degrees C. (this is 147 degrees F.). THE DOG STRUGGLED SOMEWHAT. The blood-pressure ROSE MARKEDLY. 3.45. Saline in jugular vein. Slight fall, then a quite ABRUPT RISE in blood-pressure.... THE DOG AGAIN STRUGGLED VIGOROUSLY. 3.48. Saline at 60 degrees C. (140 degrees F.). Slight RISE in blood-pressure. DOG STRUGGLED SOMEWHAT. 3.54. Saline at 60 degrees C. An immediate RISE in blood-pressure. 4.12. One-half drachm of chloroform on inhaler. 4.13. MARKED FALL in blood-pressure. 4.13. CHLOROFORM TAKEN AWAY. BLOOD-PRESSURE IMMEDIATELY AROSE to previous level. EXPERIMENT 32. A few drops of chloroform were given instead of ether, the BLOOD-PRESSURE FALLING immediately.... After a few minutes, several drops of chloroform were again administered, a marked FALL (of blood-pressure) following. One-half drachm of chloroform given, PRODUCING A GRADUAL FALL IN BLOOD-PRESSURE. On removing the chloroform, the blood-pressure recovered. At 5.30, saline stopped. Eye reflex not gone. At 5.36 THE ANAESTHESIA REMOVED. SLIGHT RISE in blood-pressure. REFLEXES NOT ABOLISHED. Does all this seem obscure to the reader? At all events, he can see that the effect of even a "few drops of chloroform" is a fall of the blood-pressure, and that when the "anaesthesia is removed" there comes the rise which is so constantly associated with sensibility. Some of the experiments related to the effect of cocaine in "blocking" sensation. These effects have long been known; the necessity of all this burning of flesh is not apparent.