Secondly, Mr. JAMES COLE, a Farmer in this parish, had a disease from the same source as related in the preceding case, and some years after was inoculated with variolous matter. He had a little pain in the axilla, and felt a slight indisposition for three or four hours. A few eruptions shewed themselves on the forehead, but they very soon disappeared without advancing to maturation. _CASE XV._ Although in the two former instances the system seemed to be secured, or nearly so, from variolous infection, by the absorption of matter from sores produced by the diseased heels of horses, yet the following case decisively proves that this cannot be entirely relied upon, until a disease has been generated by the morbid matter from the horse on the nipple of the cow, and passed through that medium to the human subject. Mr. ABRAHAM RIDDIFORD, a Farmer at Stone in this parish, in consequence of dressing a mare that had sore heels, was affected with very painful sores in both his hands, tumours in each axilla, and severe and general indisposition. A Surgeon in the neighbourhood attended him, who, knowing the similarity between the appearance of the sores upon his hands and those produced by the Cow Pox, and being acquainted also with the effects of that disease on the human constitution, assured him that he never need to fear the infection of the Small Pox; but this assertion proved fallacious, for, on being exposed to the infection upwards of twenty years afterwards, he caught the disease, which took its regular course in a very mild way. There certainly was a difference perceptible, although it is not easy to describe it, in the general appearance of the pustules from that which we commonly see. Other practitioners, who visited the patient at my request, agreed with me in this point, though there was no room left for suspicion as to the reality of the disease, as I inoculated some of his family from the pustules, who had the Small Pox, with its usual appearances, in consequence. _CASE XVI._