Whether the matter, either from the cow or the horse will affect the sound skin of the human body, I cannot positively determine; probably it will not, unless on those parts where the cuticle is extremely thin, as on the lips for example. I have known an instance of a poor girl who produced an ulceration on her lip by frequently holding her finger to her mouth to cool the raging of a Cow-pox sore by blowing upon it. The hands of the farmers' servants here, from the nature of their employments, are constantly exposed to those injuries which occasion abrasions of the cuticle, to punctures from thorns and such like accidents; so that they are always in a state to feel the consequences of exposure to infectious matter. It is singular to observe that the Cow-pox virus, although it renders the constitution unsusceptible of the variolous, should, nevertheless, leave it unchanged with respect to its own action. I have already produced an instance[2] to point out this, and shall now corroborate it with another. Elizabeth Wynne, who had the Cow-pox in the year 1759, was inoculated with variolous matter, without effect, in the year 1797, and again caught the Cow-pox in the year 1798. When I saw her, which was on the 8th day after she received the infection, I found her affected with general lassitude, shiverings, alternating with heat, coldness of the extremities, and a quick and irregular pulse. These symptoms were preceded by a pain in the axilla. On her hand was one large pustulous sore, which resembled that delinated in Plate No. 1. It is curious also to observe, that the virus, which with respect to its effects is undetermined and uncertain previously to its passing from the horse through the medium of the cow, should then not only become more active, but should invariably and completely possess those specific properties which induce in the human constitution symptoms similar to those of the variolous fever, and effect in it that peculiar change which for ever renders it unsusceptible of the variolous contagion.