JOHN PHILLIPS, a Tradesman of this town, had the Cow Pox at so early a period as nine years of age. At the age of sixty-two I inoculated him, and was very careful in selecting matter in its most active state. It was taken from the arm of a boy just before the commencement of the eruptive fever, and instantly inserted. It very speedily produced a sting-like feel in the part. An efflorescence appeared, which on the fourth day was rather extensive, and some degree of pain and stiffness were felt about the shoulder; but on the fifth day these symptoms began to disappear, and in a day or two after went entirely off, without producing any effect on the system. _CASE IV._ MARY BARGE, of Woodford, in this parish, was inoculated with variolous matter in the year 1791. An efflorescence of a palish red colour soon appeared about the parts where the matter was inserted, and spread itself rather extensively, but died away in a few days without producing any variolous symptoms[1]. She has since been repeatedly employed as a nurse to Small-pox patients, without experiencing any ill consequences. This woman had the Cow Pox when she lived in the service of a Farmer in this parish thirty-one years before. [Footnote 1: It is remarkable that variolous matter, when the system is disposed to reject it, should excite inflammation on the part to which it is applied more speedily than when it produces the Small Pox. Indeed it becomes almost a criterion by which we can determine whether the infection will be received or not. It seems as if a change, which endures through life, had been produced in the action, or disposition to action, in the vessels of the skin; and it is remarkable too, that whether this change has been effected by the Small Pox, or the Cow Pox, that the disposition to sudden cuticular inflammation is the same on the application of variolous matter.] _CASE V._ MRS. H----, a respectable Gentlewoman of this town, had the Cow Pox when very young. She received the infection in rather an uncommon manner: it was given by means of her handling some of the same utensils[1] which were in use among the servants of the family, who had the disease from milking infected cows. Her hands had many of the Cow-pox sores upon them, and they were communicated to her nose, which became inflamed and very much swoln. Soon after this event Mrs. H---- was exposed to the contagion of the Small Pox, where it was scarcely possible for her to have escaped, had she been susceptible of it, as she regularly attended a relative who had the disease in so violent a degree that it proved fatal to him. In the year 1778 the Small Pox prevailed very much at Berkeley, and Mrs. H---- not feeling perfectly satisfied respecting her safety (no indisposition having followed her exposure to the Small Pox) I inoculated her with active variolous matter. The same appearance followed as in the preceding cases--an efflorescence on the arm without any effect on the constitution.