Michael Faraday 1818 W. E. Clarke 1839 Crawford W. Long 1842 E. E. Marcy 1844 W. T. G. Morton 1846 Charles T. Jackson 1846 First surgical operation in America October 16, 1846 First surgical operation in Great Britain December 21, 1846 (Warren, Hayward, Bigelow, Boote, Robinson, Liston, Buchanan, Louget, Snow, Simpson, Bernard, Clover) CHLOROFORM Guthrie 1831 Waldie 1847 James Young Simpson 1847 First surgical operation under chloroform, in Edinburgh November 15, 1847 (Soubeiran, Liebig, Dumas, Flourens, M. Duncan, G. Keith, Snow, Nunneley, James Arnott) COCAINE Gädeke 1855 Hughes Bennett 1874 Von Anrep 1880 Koller 1884 [Illustration: ‘Wellcome’ Brand Chloroform, 1/4 lb. in drop bottle--exact size] ‘WELLCOME’ BRAND CHLOROFORM [Sidenote: Ethyl chloride] [Sidenote: Conforms to B.P.] ‘Wellcome’ Brand Chloroform represents the results of the most recent researches. It embodies the essentials of purity and uniformity, the necessary basis of a satisfactory chloroform. Some chloroforms which satisfy official standards have yet been shown to vary in composition and in effect, the result depending on the occurrence in the preparation of a small and varying quantity of ethyl chloride. ‘Wellcome’ Brand Chloroform is of constant composition and gives uniform effects. It conforms in every respect to the requirements of the B.P., and contains a small and definite proportion of ethyl chloride, which has been found to assist the satisfactory induction of anæsthesia. [Illustration: ‘Wellcome’ Brand Chloroform, 30 c.c., in hermetically-sealed tube. Length of tube, 5-1/4 in.] [Sidenote: Proved value] [Sidenote: Confidence in administration]