To attain the highest standard in these as in other preparations for medicinal use, extensive scientific research and many technical experiments have been made. Long-continued researches in the Wellcome Chemical and Physiological Research Laboratories led to the issue of ‘Hemisine,’ a physiologically standardised product which presents the active principle of the medulla of the supra-renal gland in a dry, soluble state. It is perfectly stable in all climates, and permits of the instant preparation of fresh reliable solutions possessing the characteristic hæmostatic and other properties of the supra-renal gland. Similarly, as the result of researches carried out at the Wellcome Physiological Research Laboratories, crystalline salts of a specific alkaloid, which produces the characteristic effects of ergot on the blood-pressure and the uterus, have been obtained in a state of chemical purity. To this alkaloid the scientific name “Ergotoxine” has been given. In ‘Ernutin,’ Burroughs Wellcome & Co. are enabled to present a preparation of uniform potency, containing the specific active therapeutic principles of ergot, chief of which is the alkaloid ergotoxine, in a state of purity which up to the present has never been approached. It is physiologically standardised by observation of its effects on the vaso-motor functions of the sympathetic nervous system. [Sidenote: Aconitine] ACONITINE as met with in commerce has been found to vary greatly in purity, and therefore in physiological effect. It is of the utmost importance that a definite strength should uniformly attach to so powerful a drug, and this is secured in the ‘Wellcome’ Brand product, which is free from pseudaconitine and japaconitine, and from the non-toxic aconine and benzaconine. [Sidenote: Atropine Cocaine] The alkaloid ATROPINE is, under this brand, issued free from hyoscine and hyoscyamine. COCAINE and its hydrochloride are prepared in a state of purity answering fully the most rigid tests. [Sidenote: Aloin, Crystal] ALOIN (CRYSTAL). This greatly improved product is barbaloin in well-defined crystals, and is free from resin. [Sidenote: Bismuth Salicylate] The bismuth salts have received much attention, a notable improvement being made in the quality of BISMUTH SALICYLATE. It is well known that there has been a lack of uniformity in the composition of this article, and that not infrequently preparations have been sold under this name which have consisted merely of a mixture of salicylic acid with the oxide or some salt of bismuth. ‘WELLCOME’ BRAND BISMUTH SALICYLATE is made from physiologically pure salicylic acid, and is uniform in composition. [Sidenote: Stable and soluble]