The secondary effects also vary according to the manipulations of the method which they follow. The development of reactive fever is an event which in many cases requires close watching, and while it is true that many castrated horses will manifest no subsequent illness, even to the extent of a slight elevation of temperature, others, on the contrary, show unmistakable signs of a general inflammatory condition and this is the more marked and definite as the condition of the wound has been left in a more or less complicated state. The presence of the ligature or of a portion of the cord which has yet to complete the sloughing action, following the method by cauterization and by the clamps, are sufficient to encourage the inflammatory tendency. MODES OF CICATRIZATION. The cicatrization of the wound of castration takes place in two ways. While the upper part heals by adhesive inflammation at and above the point where the amputation has been performed, it is below that point in a process of cicatrization by the second intention, the parts filling up by the development of granulations, and being accused by an abundant suppurative process. The first fact observed is that the parts become more or less swollen. The swelling is at first limited to the edges of the wound, but increases and spreads to the scrotum, then to the sheath, or even extends forwards and backwards to the perineal region. A flow of serosity will be observed almost immediately following the operation, at first thin and yellowish, but will, before the second or third day, become thicker and more purulent in character, so progressing that after that period it will become a laudable, creamy pus, in evidence of the process going forward towards the establishment of sound and healthy cicatrization. This cicatrization will proceed until the healing is complete--that is, for a period varying between thirty and forty days--the swelling slowly subsiding from the moment when the suppuration becomes established. THE HYGIENE AND THE SUBSEQUENT ATTENTION.