In more obstinate cases, which had been coming on for a longer period, or had been caused by more noxious influences, had lasted longer, had invaded the organism with more intensity, or where the paroxysms last longer and the intermissions are shorter, or where two paroxysms occur in succession, or the life of the organism is endangered by some cause or other,--the organism has to be saturated with the medicine in the shortest possible period, in order to ensure victory to the curative agent. Under these circumstances, we prepare a solution of from two to four drops of the third potency in twelve tablespoonfuls of water, shake it well in a closed bottle, and give a tablespoonful of this solution every hour. If the case should be urgent, we may give a drop of Apis 3, on sugar, every three or six hours. This treatment is to be continued until the patient is decidedly better; after which the medicine should be discontinued. If the improvement is not quite satisfactory, the last dose is continued several times every twelve or twenty-four hours, after which the proper effect will have been obtained. If the progressive improvement of the patient should be attended with distinct morbid symptoms, it would be injurious to continue the repetition of the drug. Nevertheless, a globule of Apis 30 may sometimes hasten the convalescence of the patient, and otherwise afford relief. Signs of reaction, even if more or less violent, should not deceive one. If left to themselves, they are often and speedily followed by a refreshing calm, and cannot be interfered with, as an aggravation of the symptoms, without damaging the case. These are all the rules which I have so far been able to infer from my use of Apis. Further experience will have to decide whether they apply to all periods, or only to the prevailing type of fever. I am unable to say whether Apis will prove effectual against epidemic marsh-intermittents, and if so, how the use of it will have to be modified. May it please those, who can shed light on this subject, to communicate their experience! Two other exceptions to Apis, as a universal febrifuge, have occurred to me in my practice: _The development of fever and ague in poisoned soil, and fever and ague complicated with China-cachexia._ It is peculiar to intermittent fever to excite the morbid germs which are slumbering in the organism. This is more particularly true in reference to psora. In proportion to universality of the psoric miasm, fever and ague will develop and complicate itself with psoric affections; and it is such complications that give rise to the inveterate character of intermittents and their disorganizing tendency.