These provings have been abundantly confirmed by my own experience. The use of Apis in these eruptions has been followed in my hands by the most satisfactory results; and I feel justified in recommending Apis as a most efficient remedy in these diseases, which are still wrapt in a good deal of obscurity. An additional source of satisfaction to have obtained more means of relieving human suffering. The experienced Neuman writes, in his Special Therapeutics, 2d Edit., Vol. I., Section 2, p. 681, about urticaria: "Howsoever unimportant a single eruption of urticaria may be, it becomes disagreeable and troublesome by its constant repetition, which is not dangerous, but exceedingly disturbing. It would be desirable to be acquainted with a safe method of curing this eruption, but so far, it has been sought for in vain." The same physician, speaking of pemphigus, writes in the same place, that its etiology, prognosis and treatment, are still very dubious; that it leads to extensive chronic sufferings, and often terminates fatally; and that no specific remedy is known for this disease. The more frequent opportunities we have of observing both these diseases in different individuals, the more frequently we observe them in conjunction with serious chronic maladies characterized by some specific chronic miasm, or in conjunction with the most penetrating and disturbing emotions, such as fright and its consequences; the more frequently we observe the sudden appearance and disappearance of such pustules, alternating with corresponding improvements or exacerbations in the internal organism, where we have to look on utterly powerless, as it were, the more uneasy do we feel at the mysterious nature of this malady, which, during the period of organic vigor, seems to be a sort of trifling derangement, somewhat like urticaria, but which, as the vital energies become prostrated by age, becomes more and more searching and tormenting, breaks forth again and again, exhausting the vital juices and leading irresistibly to a fatal termination; a result which is particularly apt to take place during old age, although I have likewise observed it, but rarely, among new-born infants.