If the limping, as is often the case in the severest forms of the disease, sets in gradually, almost imperceptibly and without much pain, I give at once a globule of Kali carbonicum 30. As a general rule, this one dose is sufficient to arrest the further development of the disease, and to award all danger so completely, that one, who is unacquainted with the nature of the malady, feels disposed to assert that it never existed. But if the pains continue, and are accompanied with fever, I resort to Apis 3, after Kali had been allowed to act for a day or two, mixing a drop in twelve tablespoonfuls of water, and giving a dose every hour, or every two or three hours, according as the pains come on more or less frequently. This treatment is continued until the patient is quieted, after which the two remedies are permitted to act without any further repetition of the medicine. If the inflammation of the joint sets in suddenly and with a violent fever, as is often the case after violent commotions, castigations, etc., we prepare a solution of Aconite in the same manner as the Apis, and give these two medicines in alternate tablespoonful doses every hour. After these two solutions are finished, and the first assault of the disease has been controlled, we give a globule of Kali 30, and permit it to act for twenty-four hours. After this period we again give Apis every hour, two or three hours, as above, until the pains cease, after which Kali is allowed to act until the disease is entirely cured. If suppuration and caries of the joint have already set in, no matter whether the pus has found an outlet in the region of the joint itself, or burrows down the thigh to find an outlet somewhere else, Kali is no longer sufficient, Silicea has to be exhibited; it is more homœopathic to caries than other anti-psorics. We give a globule of Silicea 30, and allow it to act for two or three days, after which a drop of Apis 3, is repeated morning and night, until the pains--which may require a more frequent exhibition of the drug--cease, and a healthy pus is secreted. After this change is accomplished, Silicea is sufficient to complete the healing of the osseous disorganization, and should be left undisturbed to the end of the treatment.