Although the three motives may and often do coexist in the same individual, or may animate him at different periods of life, the fact remains that they are quite distinct. Thirst and taste do not lead to excessive drinking; and there is good evidence that the degree of concentration and the dosage are important factors in the amount of harm alcohol may do to the individual. The concern of evolutionists, therefore, is with the man who is so constituted that the mental effects of alcohol acting directly on the brain are pleasing, and we must show that there is a congenital variability in this mental quality, among individuals. Surely an appeal to personal experience will leave little room for doubt on that point. The alcohol question is so hedged about with moral and ethical issues that those who never get drunk, or who perhaps never even "take a drink," are likely to ascribe that line of conduct to superior intelligence and great self-control. As a fact, a dispassionate analysis of the case will show that why many such do not use alcoholic beverages to excess is because intoxication has no charm for them. He is so constituted that the action of alcohol on the brain is distasteful rather than pleasing to him. In other cases it is variation in controlling satisfaction of immediate pleasures for later greater good. Some of the real inebriates have a strong will and a real desire to be sober, but have a different mental make-up, vividly described by William James:[19] "The craving for drink in real dipsomaniacs, or for opium and chloral in those subjugated, is of a strength of which normal persons can have no conception. 'Were a keg of rum in one corner of the room, and were a cannon constantly discharging balls between me and it, I could not refrain from passing before that cannon in order to get that rum. If a bottle of brandy stood on one hand, and the pit of hell yawned on the other, and I were convinced I should be pushed in as surely as I took one glass, I could not refrain.' Such statements abound in dipsomaniacs' mouths." Between this extreme, and the other of the man who is sickened by a single glass of beer, there are all intermediates. Now, given an abundant and accessible supply of alcohol to a race, what happens? Those who are not tempted or have adequate control, do not drink to excess; those who are so constituted as to crave the effects of alcohol (once they have experienced them), and who lack the ability to deny themselves the immediate pleasure for the sake of a future gain, seek to renew these pleasures of intoxication at every opportunity; and the well attested result is that they are likely to drink themselves to a premature death.