Thus, it appears that the epidemic or Asiatic Cholera, from its first irruption on the northern coast, spread over the greater part of the North American Continent in the space of two years, and has several times reappeared in different sections in its peculiar malignant character, spreading on each occasion over a greater or less extent of territory with the same uniform and destructive influence. Neither time, nor science, nor professional skill has thus far appeared to soften its character, or mitigate its severity. When the disease had fully assumed its epidemic or malignant type in India, in 1817, its rate of mortality was everywhere in that vast territory excessively high. According to the most reliable reports, the cases occurring in the earlier period of an irruption were generally fatal, few only surviving the attack; while of those occurring when the disease was on the decline, a greater proportion recovered. We read of numerous instances where one-third, one-half, two-thirds, and even nine-tenths of those seized with Cholera perished, and again of some places where one-fifth, one-fourth, and in some instances one-third of entire populations were cut off in a very short period by this disease. But without attempting to give the statistics of cholera in this part of the world, or even in Europe or America, we may present a few instances of mortality, going to show the great percentage of loss by this singular disease during its ravages from 1817 to 1837. In Siam, it is said 20,000 persons fell victims to it in twelve days. The inhabitants are remarkable for their uncleanly habits, and crowded, ill-ventilated tenements. In Sicily, 16,000 died of cholera in 1832, at Catania; in Palermo, 40,000. These cities are represented as being filthy in the extreme, and the personal habits of the people so uncleanly, and the houses so crowded, that it is a matter of surprise the mortality was not greater. In Bassorah and Bagdad, situated in low, unhealthy localities, and exposed to a damp, insalubrious atmosphere, which, in the warmer season, is often essentially impregnated with miasmata and offensive exhalations from animal and vegetable decomposition, both within and without their inclosures, it is affirmed that more than one-third of their entire populations were carried off in less than one month. In the Province of Caucasus, out of 16,000 attacked by the disease, 10,000 died. In Russia, out of 54,000 attacked in 1830, it is said more than 31,000 died. In Hungary, it is reported that the whole number affected by the disease was about 400,000, of whom more than one-half died. It is officially stated that the total number--the military excepted--of those affected with cholera in France, from its first appearance at Calais, March 15, 1832, to January 1st, 1833, is 230,000, and the deaths 95,000.