Such are some of the prominent appearances which the body has presented when the patient has died in the first, or pulseless stage of the disease. But in other cases, where the premonitory stage has been definitely marked, and attended with diarrhoea or other depressing disorder affecting the alimentary canal, and where the patient has continued under the influence of the disease for a longer period, and has passed through the usual successive stages of it, other additional appearances have been noticed, which are here omitted, as they are of a secondary importance, and belong especially to the more protracted cases. The _post-mortem_ appearances, the phenomena of the disease, the Algide, or diminished animal heat, and the loss of nervous power, all tend to show an obstructed circulation and consequent embarrassment of respiration resulting in the non-aeration and non-oxydation of the blood, from which a long train of secondary and non-essential symptoms arise. For it is affirmed that the mechanical part of respiration remains in a good degree perfect, and that the heart evidently continues to beat in many cases till stopped by the want of blood in the left side and by its accumulation in the right side. Hence, for the cause of this arrest of the circulation of the blood through the lungs, we are forced to look to the condition of the blood itself, and the deranged action of the ganglionic nerves. Attempts have been made to trace out from analysis the exact chemical changes in the order of their occurrence which attend the period of transudation from the blood into the intestinal canal. "The most prominent phenomena of cholera," says Dr. Aiken, "during this period of transudation, consists in separation of the water and of the salts of the intercellular fluid (of the blood) through the mucous membrane of the intestinal canal, and the retention in the blood of an important excess of albumen and of blood-cells, with apparently less, but in reality with great diminution of the salts and fibrin."