If we trace the action of calomel, the use of opium, the effect of cupping, bleeding, blistering, etc., etc., we shall obtain no very desirable information; nothing valuable tending to indicate a correct principle of practice. If we go still further, and examine the tendency and effects of the various baths exhibited at Scutari, the use of the flesh-brush, the bare hand, the heated sand, the embrocations, the turpentine and other irritants, the boiling water, or the burning alcohol, skinning and cooking the patient alive, we shall be shocked at the enormous cruelty and barbarity that have been pursued, and turn from the repulsive exhibition, without discovering one ray of light to guide us in the right direction. Disappointed and baffled in our inquiries, shall we here abandon our investigations and dismiss the whole subject, because our course is involved in difficulties? Would intelligence and reason justify the neglect to improve the means at command? We think not; but rather induce us to advance in search of truth if the elements of success are not quite exhausted. Let us be encouraged and stimulated to untiring perseverance so long as there remains any experiment untraced and uninvestigated in its bearing upon the direct action of the disease. Had Dr. Aiken, or those other eminent surgeons who took part in those numberless experiments, instituted on the Continent and in England, especially those who initiated the process of injecting into the veins a solution of soda raised to a temperature from 105° to 120° Fahr., continued their investigations patiently and assiduously, they might probably have discovered long ago the correct theory of practice for the treatment and cure of cholera. But they failed to see, or, if they saw at all, rejected the feeble ray of light struck out by the experiments in which they had themselves participated, and like the celebrated Dr. Hunter, who refused to listen to the discoveries made by his pupil, the indefatigable Jenner, who traced the identity of the variola with the common disease affecting the kine; and thence extracted the vaccine lymph and established a principle by which that loathsome disease and often recurring epidemic has been nearly banished from the earth. Though they have thus failed, they have nevertheless left on record, in unmistakable language, the result of their bold experiments, which we may investigate, and appropriate the instruction drawn thence for our own and the advantage of our fellow-men.