A general breakthrough in control of plant diseases is yet to come. Because of thousands of pathogenic species, with hundreds of strains, it does not seem possible that the following questions could be answered about each one. What is the life cycle of the microbe? What conditions of temperature and humidity encourage it to spread? What plant species does it attack? How does it enter? What chemical changes within the cells of the plant determine whether they resist or succumb to the invader? How long can germs remain potent? How far can they travel by wind or water? What combination of resistant varieties, cultural methods, and chemical treatment will control the disease? With tracers it is possible for the first time to measure chemical uptake in single spores and to follow chemicals through the plant. Perhaps the most enlightening information from such studies is that some fungicides are 10,000 times less effective per unit of “body weight” than are other chemicals used to destroy weeds and insects. Obviously the breakthrough in chemical control of plant diseases is yet to come. Why Do Chemicals Destroy Some Plants? Weeds cost this country an estimated $5 billion annually, which is more than the loss to either plant diseases or insects. Selective chemical weed killers such as “2, 4-D” have become so widely used that more than $135 million worth was sold in the United States in 1959. In proper concentration these compounds will destroy many unwanted plants without harming lawn grasses or crop plants. [Illustration: Fig. 3—Tagged weed-killing chemicals (A) are taken in and transported alike in grassy (B) and broad-leaved (C) plants, but only in the latter are killed.] As in many other instances, beneficial use of the chemicals has far outreached an understanding of how they work. The still scanty knowledge of the process has come almost entirely from tracer studies. All plants readily absorb selective weed killers (“herbicides”), which are not destroyed within the plants. Resistant plants show no effect of the chemicals, but sensitive plants suffer damage in actively growing roots and shoots. Sugar formation during photosynthesis is disrupted in these plants, and phosphorus movement is retarded. In order to predict what new classes of chemicals might be of value as herbicides, we must await the results of research using radioactive tracers. Animal Nutrition and Metabolism How Nutritious Are Various Feedstuffs? An endless phase of animal nutrition research deals with efficiency of rations, that is, the pounds gained by the animal per pound of feed consumed. The standard form of such research is to feed groups of animals on different rations for several weeks or months and determine average change in weight per pound of feed used.