In sheep the post-mortem examination showed paleness, anæmia of the muscles, and great distention of the abdomen. The intestines were found filled with gases, and the mesenteric blood vessels filled with blood. No peritonitis, or ascites, or ecchymoses in the mucous membranes were noted in the autopsies made on sheep by Ruedi. The liver has been seen enlarged. In sheep the brain was anæmic. Microscopically the brain showed atrophy and the Purkinjie's cells disappeared or their processes atrophied. In these sheep the brain was so anæmic that the distinction between the gray and the white matter was hard to define.[78] The membranes of the cord have been found inflamed and adherent, but the spinal cord was usually normal.[79] In some cases, however, the spinal cord has been found softened[80] and oedematous. The arteries of the limbs were gorged with blood,[81] and at the same time there was a collection of serum in the abdominal cavity. Death is thought to be due to starvation.[82] In other words, the pathological condition, according to published accounts, shows little that is characteristic save some action on the gastro-intestinal tract. * * * * * FOOTNOTES: [71] Anderson, F. W. Poisonous Plants and the Symptoms They Produce. Bot. Gaz., vol. 14, p. 180. 1889. [72] Sayre, L. E. Loco Weed. Amer. Vet. Rev., vol. 11, p. 558. 1887. [73] O'Brine, D. Progress Bulletin on the Loco and Larkspur. Colo. State Agric. Coll. Bul. 25, p. 12. 1893. [74] Faville, in O'Brine, D. Progress Bulletin on the Loco and Larkspur. Colo. State Agric. Coll. Bul. 25, p. 11. 1893. [75] Sayre, L. E. Loco Weed. Amer. Vet. Rev., vol. 11, p. 559. 1887. [76] Stalker, M. The "Loco" Plant and Its Effect on Animals. Bur. Animal Industry, 3d Ann. Rept. (1886), p. 274. 1887--Sayre, L. E. Loco-Weed. Amer. Pharm. Assoc. Proc., vol. 38, p. 108. 1890.--O'Brine, D. Progress Bulletin on the Loco and Larkspur. Colo. State Agric. Coll. Bul. 25, pp. 16, 17. 1893. [77] Mayo, N. S., l. c., p. 118. [78] Ruedi, C. Loco Weed (Astragalus Mollissimus): A Toxico-Chemical Study. Trans. Colo. State Med. Soc., 1895, p. 418. [79] Sayre, L. E. Loco Weed. Amer. Vet. Rev., vol. 11, p. 559. 1887. [80] O'Brine, D. Progress Bulletin on the Loco and Larkspur. Colo. State Agric. Coll. Bul. 25, p. 12. 1893.--Klench, J. P. Rattleweed or Loco Disease. Amer. Vet. Rev., vol 12, p. 399. 1888. [81] Anderson, F. W. Poisonous Plants and the Symptoms They Produce. Bot. Gaz., vol. 14, p. 180. 1889. [82] McCullaugh, F. A. Locoed Horses. Journ. Comp. Med. and Vet. Archives, vol. 13, p. 436. 1892. =HISTORICAL SKETCH OF LOCO INVESTIGATIONS FROM A PHARMACOLOGICAL STANDPOINT.=