An albuminoid which was obtained by precipitating a concentrated aqueous extract of _Astragalus mollissimus_ by means of alcohol likewise was found to be inactive to a kitten in doses corresponding to 50 grams of the crude plant. A globulin which was isolated by precipitation from a 10 per cent sodium chlorid solution proved also to be inactive in doses of 0.2 gram. They then extracted 3 kilograms of these plants with 1/2 per cent sulphuric acid, and after evaporation to a thick gum the mass was extracted with strong alcohol, the alcoholic solution was evaporated, and the alcoholic residue taken up in water and precipitated by neutral and basic lead acetates, and after removing the lead with sulphureted hydrogen the filtrate gave precipitates with various alkaloidal reagents. The sirupy residue which they obtained from _Astragalus mollissimus_ by decomposing the precipitate with Mayer's solution administered to kittens in doses of 0.1 gram produced merely frothing at the mouth with profuse flow of saliva, but the animals soon recovered. The presence of a large amount of calcium was shown but not estimated quantitatively. Power and Cambier summed up their conclusions by stating that both the Astragalus and the Crotalaria contain very small amounts of toxic alkaloids, to which they believe the symptoms of poisoning produced were due. Their work from a chemical standpoint is excellent, but from a pharmacological point of view seems to be deficient; in fact, Power does not claim to be a pharmacologist. What would seem to be the proper course would have been to test for themselves the action of the plant on various animals and, after deciding which reacted most characteristically, test, after various precipitations, both the precipitates and filtrates on various animals to see whether the original symptoms and pathological lesions could be produced. They failed, however, to test their mother substance. It is well recognized that plants grown under varying conditions and on different soils vary in the amount of the physiologically active principle they contain. In the case of Crotalaria, Power and Cambier had before them the experiment of Stalker, in which he reproduced the disorder by feeding the plant extract to horses, yet they claimed that the body which they administered was the active principle, merely because it produced some frothing at the mouth and salivation in a kitten. The percentage of active principle they found would be too small to account for the symptoms, except in the case of a very active compound. Certain of these precipitates were also later examined physiologically by O'Brine.[111] He also found the resin precipitated from an alcoholic extract of the plant and also the alcoholic extract from 2.2 pounds of the dried _Astragalus mollissimus_ to be physiologically inactive.