to my experiments the loco-weed works slowly but surely; as soon as the anæmia of the brain sets in, the animals act in every respect mad like; one hour they are excitable, and then again dull and languid as can be. The rabbits eat, when well, very quickly, and whenever they have opportunity; not so the locoed rabbit; he eats slowly for a minute or two, then he goes into a corner and meditates, comes forward to nibble at a carrot or a piece of cabbage, but he never eats greedily, and does not steal it from the mouth of his neighbor, or only very exceptionally. I observed these rabbits for ten days; they did not die, because I gave them weaker solutions; but they all became very ill, and as I had to leave the park I killed them with the needle inserted into the medulla oblongata, and made the post-mortem. In all of these cases I found great congestion in the abdomen, and marked anæmia of the brain. The congestion of the vena portæ commences certainly very early, but still the first symptoms are the nervous symptoms, first as excitants, then depressing or sedative, with a marked hyperæsthesia of the cutaneous nerves. Ruedi made an attempt to isolate the active principle and separated a base, which he calls "locoin," from an ether shaking. This base, however, he found to be physiologically inactive, but believes the activity to be due to a body which he calls "loco-acid," which is present in the mother liquid after the shaking with ether. He, however, has not obtained this in any degree of purity and gives no chemical data to substantiate this statement save that the fluid was acid. Experiments made at the University of Pennsylvania with certain loco plants on cats, dogs, and rabbits proved negative.[119] Other experiments on rabbits have been made by Doctor Lewis. These rabbits were fed on the leaves, stem, and whole plant, and also extracts of one of the loco plants (presumably _Astragalus mollissimus_) for one or two months, without producing any noticeable effect.[120]