NOTE.--The writer wishes to acknowledge the great literary help Mr. Chesnut's card catalogue has been to him in the preparation of this paper. [139] Unpublished report. [140] Marshall, H. T. Loco Weed Disease of Sheep. Johns Hopkins Hospital Bul., vol. 15, p. 182. 1904. [141] Payne, J. E. Cattle Raising on the Plains. Colo. Agric. Expt. Sta. Bul. 87, p. 16. 1904. [142] National Standard Dispensatory, p. 868. 1905. NOTE.--The field experiments of Harding and Tudor are rather conclusive as to the relation of these plants to this disorder. Sayre, L. E., Loco Weed, Amer. Vet. Rev., vol. 11, pp. 553-554, 1887--Blankinship, J. W., Loco and Some Other Poisonous Plants in Montana, Mont. Agric. Exper. Sta. Bul. 45, pp. 83-84, 1903--Loco Disease, Therap. Gaz., vol. 12, p. 30. 1898. =NOTES ON VARIOUS MEMBERS OF THE LOCO-WEED FAMILY.= _Astragalus caryocarpus_ is at times eaten in some of the Western States, but is claimed by some at certain stages of its growth to contain a poisonous principle. Frankforter,[143] from experiments on himself, however, denies this. _Astragalus glycophyllus_ has been used as a diuretic and _Astragalus exscapus_ in the treatment of syphilis.[144] "The seed of _A. boeticus_, planted in Germany and England, are found to be the very best substitute for coffee yet tried, and so used--roasted, parched, and mixed with coffee."[145] _Astragalus nuttallianus_, according to Smith,[146] is a highly nutritious forage plant in spring. _Astragalus crassicarpus_ has been prophesied by him to be a valuable addition to early spring soiling crops. _Astragalus adsurgens_ (_nitidus_) and one or two other species of Astragalus are still used in Chinese medicine.[147] The Indians of the Southwest are familiar with certain loco plants.[148] The Tewans of Hano are said to eat the root of _Aragallus lamberti_, and _Astragalus mollissimus_ is applied locally for headaches by some of the Arizona Indians. One of these species is used as a flavoring material by the Coahuillas and is mixed with other plants as spices.[149] _Astragalus kentrophyta_ had a reputation among the Navajos for the treatment of rabies.[150] The use of certain loco plants--_Astragalus mollissimus_--has been advocated on theoretical grounds in the treatment of certain forms of insanity, but without favorable results.[151] In Peru and Chile _Astragalus garbancillo_, _A. unifultus_, and _A. ochroleucus_ have been considered injurious to animals.[152] _Astragalus glyciphyllus_ and _A. alpinus_ have been used in Europe as food for stock.[153] Details as to the use of other Astragali can be found in Planchon, G., Sur les Astragales, in Journal de Pharmacie et de Chimie, 5th series, vol 24, p. 473, 1891; 5th series, vol. 25, pp. 169, 233, 1892. * * * * * FOOTNOTES: