In a rabbit the application of 0.66 gram of barium chlorid to a wound was followed in twenty minutes by convulsions, paralysis, and finally coma and death.[195] Of barium nitrate 0.66 gram mixed with sugar and fed to a rabbit caused death in less than one hour, and 0.33 gram induced death in another rabbit in twenty-seven hours.[196] Six grains (0.4 gram) of barium iodid fed in solution to a rabbit caused death the following day. On this day there were tremors of the neck and shoulders with convulsive movements of the limbs. There was also grinding of the teeth. "The mucous membrane of the stomach was rose-red at the cardia, and softened." Membranes of the cord and brain also were congested.[197] For rabbits weighing 1,500 to 2,000 grams the lethal dose of barium chlorid on subcutaneous use is stated to be 0.05 to 0.06 grams.[198] A rabbit weighing 1,106 grams was fed with a solution containing 50 milligrams of crystallized barium acetate c. p. and 50 milligrams of zirconium chlorid (pure). In fifty-seven minutes the animal showed difficulty in moving the fore legs, developing marked paralysis of the same about five hours later, and died the following morning--that is, twenty-two hours after feeding. The heart was found dilated, kidneys congested, stomach walls pink and covered in places with mucus and partly digested blood, and cerebral dural vessels dilated, but no clots were seen; bladder full. Mixtures of 0.5 gram of calcium acetate and 50 milligrams of barium acetate failed to kill. Mixtures of titanium and barium were not tried, as no titanium salt soluble in water and of neutral reaction was accessible. Mittelstaedt called attention to the fact that pregnant rabbits were more easily affected by the barium administration than nonpregnant ones, and noted abortion in one case.[199] One gram of the barium carbonate killed a dog in eight hours. A second dog died in fifteen hours. Both of these animals vomited so that a portion of this must have been lost.[200] Barium carbonate was formerly employed as a rat poison.[201] Of barium chlorid 0.6 gram, fed in aqueous solution, caused death in a dog in forty-eight minutes if vomiting was prevented.[202] In Tidy's hands 2 grams of the barium nitrate caused death in a small terrier in three and three-fourth hours. This dog had slight convulsions, was almost unable to stand, and had vomiting and purging. The reflexes were diminished. A small dog recovered only completely in five days after being fed 0.66 gram, while a large dog after being fed 1.3 grams only recovered after two days. In cats 0.8 gram of barium carbonate when introduced into a wound caused on the third day languor, slow respiration, feeble pulse, twitching of hind legs, dilated pupils, and death.[203] * * * * * FOOTNOTES: [192] Magnus, R. Wirkungsweise u. Angriffspunkt einiger Gifte am Katzendarm. Archiv. f. Gesam. Physiol., vol. 108, p. 44, 1905.