[200] Pelletier, D. Observations sur la Strontiane. Annal. de Chimie, vol. 21, p. 119. 1797. [201] Christison, R. Treatise on Poisons. Edinburgh, 1845, p. 579.--Crampe. Bewährte Mittel gegen Feldmäuse. Deutsch. Landw. Presse, vol. 5, p. 530. 1878.--Felletar, E. Fälle von Intox. mit kohlensäur. Baryum. Pest. Med.-Chir. Presse, vol. 28, p. 1072. 1892. [202] Husemann, T. Ein Beitrag z. Kennt. d. Barytvergiftungen. Zeits. f. pract. Heilk., vol. 3, p. 235. 1866. In this article Husemann has collected many cases of poisoning by barium in animals. [203] Christison, R. Treatise on Poisons. Edinburgh, 1845, p. 579. =BARIUM POISONING IN MAN.= The high toxicity of barium was called attention to by early observers, but it was attributed by some to admixed arsenic. The reports of feeding experiments with barium on animals have varied markedly, but now care is being advised in the use of barium salts.[204] Barium was introduced into medicine in the treatment of scrofula, but has fallen into disuse, and only recently attention has been called to it on account of its action on the circulatory system. Filippi,[205] however, says, "The effects on the heart and on the pressure are already the first indication of poisoning." This metal has also been used in the treatment of chronic diseases of the spinal cord, as multiple sclerosis and paralysis agitans.[206] After the administration to a woman of 1/12 grain (0.005 gram) of barium chlorid three to five times a day for a few days, a total of 2-1/4 grains (0.135 gram), the patient developed rapid respiration, tenderness over the epigastrium, nausea, constipation, cramps in the limbs, loss of appetite, weakness, great emaciation, dysuria, some deafness with tinnitus, difficulty in speaking and thinking, with vertigo.[207] In this case the eyes were glassy, the vision indistinct, and the cheeks flushed. Kohl after the use of small doses of the same noted salivation, swelling of the gums, and falling out of the teeth, with a mercurial odor to the breath. Christison[208] states: "I have known violent vomiting, gripes, and diarrhea produced in like manner by a quantity not exceeding the usual medicinal doses." According to Kennedy few persons are able to bear 1/8 grain (0.0075 gram) of barium chlorid.[209] In Carpenter's case after three doses of 1.6 grains (0.070 gram) of barium chlorid the patient developed almost lethal symptoms.[210] Carpenter calls attention to the drowsiness which developed in this patient after the administration of barium, a fact which had already been noted by Christison.[211]