A cartarrhal affection of various mucous membranes and a swelling of various glands have been noted, especially of the lymph and salivary glands, and in the male the testes have at times swollen.[212] The inflammation of the glands may pass on to suppuration. The skin becomes dry and shows a tendency to crack. Febrile attacks are reported after the repeated use of small doses of barium. Scheibler[213] has called attention to the possibility of producing _chronic_ barium poisoning in man from the use of barium in the manufacture of food products. Acute cases of poisoning in man from four or more grams of barium carbonate or chlorid or nitrate have been reported more or less frequently.[214] In the acute case of poisoning in man reported by Tiraboschi and Taito, no macroscopic changes were noted in the stomach mucosa.[215] Lopes[216] has reported one case of acute poisoning in man from less than 1 gram of barium chlorid. In this case paralysis of the limbs was a marked feature. Stern[217] cites Perondi and Lisfranc to the effect that "remarkably large doses of barium chlorid can be borne without injury by gradually increasing the doses (dissolved in much water)." Lisfranc[218] has suggested that the sensitiveness to poisoning by barium salts is greater in certain climates than in others. No data are as yet available as to the influence of altitude and partial starvation on the toxicity of barium salts. As is well known, almost all recorded cases of locoed animals have occurred at a high altitude. It must also be remembered that the addition of one salt to the solution of another may greatly increase the toxicity of the first one. Thus, the addition of a few milligrams of barium chlorid to a solution of a sulphocyanate renders the latter much more poisonous.[219] This may be due to the fact that the salts are more completely ionized. * * * * * FOOTNOTES: [204] According to v. Jaksch, "Sie ist bei der grossen Toxicität der Substanz immer ernst zu stellen." Vergiftungen, 1897, p. 79. NOTE.--A thorough pharmacological study of some barium salt is much needed, and it is hoped that the writer will be able to complete this work. [205] Filippi, E. Modificaz. del Ricambio Organice per Azione del Cloruro di Bario. La Sperimentale, vol. 60, p. 610. 1906; Sull' Azione Cardiaca del Chloruro di Bario. Archivio di Farmacol. Speriment., vol. 5, p. 122. 1906. [206] Schulz, H. Vorles. ü. Wirkung. u. Anwendung d. unorganisch. Arzneistoffe. Leipzig, 1907, p. 234.--Hare, H. A. Use of Barium Chloride in Heart Disease. Med. News, vol. 54, p. 183. 1889. [207] Ferguson, J. C. Symptoms of Poisoning from Muriate of Barytes. Dublin Quart. Journ. Med. Sci., vol. 1, p. 271. 1846. [208] Christison, R., l. c., p. 580. [209] Kennedy, H. Dose of the Muriate of Barytes. Lancet, vol. 2, p. 28. 1873.