[218] Lisfranc. Leçon sur l'Emploi du Muriate de Baryte contre les Tumeurs Blanches. Gaz. Méd. de Paris, 2 s., vol. 4, p. 215. 1836. [219] Pauli, W., and Fröhlich, A. Pharmakodynam. Studien. Sitz. Kaiserl. Acad. d. Wissens. z. Wien, vol. 115, III, pt. 6, p. 445. 1906. =PATHOLOGICAL LESIONS IN EXPERIMENTAL BARIUM POISONING.= The post-mortem examinations in cases of acute experimental barium poisoning, according to Schedel,[220] show punctiform or large hemorrhagic effusion in the fundus ventriculi[221] and in the large and small intestines, contraction of the bladder, and hemorrhage into the walls of the bladder and uterus. The heart is usually found relaxed or the left ventricle contracted in systole, while the right is relaxed. Only once were ecchymoses under the endocardium seen. The liver and kidneys showed nothing special. The urine was free from albumen and sugar. In a few cases the lungs showed some infiltration with blood. In chronic cases, according to our own investigations in rabbits, there are no characteristic macroscopic lesions, a result which agrees with Mittelstaedt's report.[222] Nothnagel and Rossbach[223] claim that in chronic poisoning by barium the peripheral nerves are altered. The same negative results have also been reported in chronic poisoning in higher animals. Reynolds[224] noted a layer like a blood clot under the cerebellum in a horse fed with barium chlorid. Fuchs[225] has called attention to the fact that the flesh of cattle poisoned with barium chlorid was harmless, perhaps owing to a conversion into an insoluble salt, a fact which may be considered in the use of locoed animals for food. * * * * * FOOTNOTES: [220] Schedel, H. Beitr. z. Kennt. d. Wirkung des Chlorbariums. 1903, p. 13. [221] After subcutaneous injection of barium chlorid, Lewin, by means of the spectroscope, has found barium in the stomach walls. Lewin, L. Schicksal körperfremder chem. Stoffe im Menschen u. besonders ihre Ausscheidung. Deutsch. Med. Woch., vol. 32, p. 173. 1906. [222] Mittelstaedt, F. Ueber chronische Bariumvergiftung. Dissert., Greifswald, 1895, p. 29. [223] Nothnagel, H., and Rossbach, M. J. Handb. d. Arzneimittel, p. 81. 1904. [224] Reynolds, M. H. A Study of Certain Cathartics. Minn. Agric. Exper. Sta., 15th Ann. Rept. 1907. [225] Fuchs, C. J. Vergiftungsfälle durch salzsäuren Baryt beim Rindvieh. Thierärztl. Mittheil., vol. 5, p. 159. 1870. Fuchs suggests that further investigations on this point are desirable. The literature of this class of experiments is very scanty. See Fröhner and Knudsen, Einige Versuche über d. Geniessbarkeit d. Fleisches vergift. Thiere. Monats. f. Prakt. Thierheilk., vol. 1, p. 529. 1890. =TOXICITY OF VARIOUS AQUEOUS EXTRACTS OF LOCO PLANTS.=