(5) A close analogy exists between the clinical symptoms and pathological findings in barium poisoning and those resulting from feeding extracts of certain loco plants. Small doses of barium salts may be administered to rabbits without apparent effect, but suddenly acute symptoms set in analogous to what is reported on the range. (6) The administration of sulphates, especially epsom salts, to form insoluble barium sulphate would be the chemical antidote which would logically be inferred from the laboratory work, but of necessity this would have to be frequently administered and its value after histological changes in the organs have occurred remains to be settled. But even the treatment of acute cases of barium poisoning in man is not always successful, even when sulphates combined with symptomatic treatment are employed. The conditions under which the sulphates fail to precipitate barium must be considered. At present it seems best to rely on preventive measures rather than on antidotal treatment. (7) Loco plants grown on certain soils are inactive pharmacologically and contain no barium. In drying certain loco plants the barium apparently is rendered insoluble so that it is not extracted by water, but can usually be extracted by digestion with the digestive ferments. (8) The barium to be harmful must be in such a form as to be dissolved out by digestion. (9) In deciding whether plants are poisonous it is desirable not merely to test the aqueous or alcoholic extract, but also the extracts obtained by digesting these plants with the ferments which occur in the gastro-intestinal tract. (10) It is important that the ash of plants, especially those grown on uncultivated soil, as on our unirrigated plains, be examined for various metals, using methods similar to those by which rocks are now analyzed in the laboratory of the United States Geological Survey. (11) It is desirable to study various obscure chronic conditions, such as lathyrism, with a view to determine the inorganic constituents of lathyrus and other families of plants. * * * * * FOOTNOTES: [251] Résumé of the results of the loco-weed investigations carried on by the Bureau of Plant Industry was issued as Bulletin 121, part 3, Bureau of Plant Industry, on January 28, 1908, in the form of papers by C. Dwight Marsh and Albert C. Crawford, respectively, under the titles "Results of Loco-Weed Investigations in the Field" and "Laboratory Work on Loco-Weed Investigations." INDEX. Page. Abortion, cows, caused by loco poisoning, 13 rabbits, caused by loco and barium poisoning, 41, 42, 62 Acid, acetic, found in loco-weed, 26 Acqua, C., reference to work, 52 Africa, South, goat disease, 17