Then, too, Newtonian science buttressed the principle of natural rights. Sir Isaac Newton demonstrated mathematically that the universe was governed by a fagot of immutable, universal, and harmonious physical laws. These were capable of being apprehended through reason. Now even as reason discovered the matchless physical harmony, so could reason, men argued, ferret out unvarying, universal principles of social-political rights. These principles constituted natural rights, natural to the extent that all men had the power, if not the capacity, to discover and learn them through use of their native reason. Newton demonstrated the validity of physical law: Locke sanctioned the supremacy of reason. Since Franklin was himself motivated by Newtonian rationalism and was a student of Locke, there is reason to believe that he was vibrantly aware of the extent to which the scientific-rationalistic ideology lent sanction to man's timeless quest for the certitude of "natural rights," antecedent to all laws. Franklin's mission to London in 1757 as Pennsylvania agent may be understood through an examination of _An Historical Review of the Constitution and Government of Pennsylvania_ (London, 1759).[i-282] If not written by him, at least "the ideas are his." Convinced that the proprietors "seem to have no regard to the Publick Welfare, so the private Point may be gained--'Tis like Firing a House to have Opportunity of stealing a Trencher,"[i-283] Franklin knew that a brilliant attack had to be made were he to intimidate the proprietary government into assuming its charter responsibilities and granting the colonists what they considered to be inviolable rights. By 1758 his "Patience with the Proprietors is almost tho' not quite spent."[i-284] A few months later, impatient with unresponsive officials, he wrote to Joseph Galloway: "God knows when we shall see it finish'd, and our Constitution settled firmly on the Foundation of Equity and English Liberty: But I am not discouraged; and only wish my Constituents may have the Patience that I have, and that I find will be absolutely necessary."[i-285] In 1759 Franklin still found the proprietors "obscure, uncertain and evasive," and was acutely virulent in despising Rev. William Smith, who was in London attacking him and the Quaker Assembly's demands.[i-286] In the same letter to Galloway he uttered a thought which he sought to develop during his second trip to London as Assembly agent in 1764: "For my part, I must own, I am tired of Proprietary Government, and heartily wish for that of the Crown."