During these years in which Cheshire was assuming a greater share of diocesan work, his parochial and missionary duties in and outside of Charlotte were not neglected. The only serious criticism of his services which was brought to his attention by his parishioners was that the missions in Iredell and Mecklenburg counties demanded too much of his time. Cheshire, however, maintained that in serving the rural missions he was at the same time building up St. Peter's, since the missions would eventually furnish many new members to the town parish. In spite of this criticism, he continued his missionary and institutional work. In 1885 and 1886 he gave wholehearted assistance to Rev. Edwin A. Osborne in establishing the Thompson Orphanage in Charlotte as a diocesan institution. The last parochial enterprise of St. Peter's Church in which he participated was the founding of the Good Samaritan Hospital for Negroes. The movement for the hospital was initiated by Mrs. John Wilkes, with whom Cheshire co-operated in every way. He devoted much time to raising the money for the purchase of a lot. In 1888 he laid the cornerstone of the hospital and three years later officiated at its formal opening. The Good Samaritan was the first hospital for Negroes to be established in North Carolina. In the course of his pastorate in Charlotte Cheshire was on the friendliest of terms with the ministers of the other denominations, although he sometimes strongly differed with them. He was a member of the local Ministerial Association, serving for a time as its vice-president. The association often passed resolutions inviting popular preachers to hold revivals in Charlotte. Cheshire, not in sympathy with professional revivalists, customarily opposed this procedure.