At the date of the death of Claude of Lorraine, Charles V. was the sole survivor of the three remarkable sovereigns who had simultaneously filled the three most important European thrones. With him the Duke and Cardinal now impelled Henry II. into a war, which had for its real object the realisation of a bold and extensive scheme greatly to increase the authority of France in Europe, and at the same time to establish the omnipotence of the Guises in France. One of the most remarkable events of this war was the siege of Metz, in which large ill-fortified place the Duke, with a small number of men, was exposed to the assaults of an army consisting of one hundred thousand infantry, twenty-three thousand horse, and one hundred and twenty pieces of artillery. Guise displayed extraordinary skill and energy, leading sorties himself, and even issuing forth at the head of a mere handful of men to skirmish with the enemy. Fortunately he had had time to lay in good store of provisions; but his cannon were few in number and for the most part unserviceable, and he was fain to defend with falconets and other small guns, the breaches which the Imperialists soon made in his walls. In an action that occurred during the siege, in the neighbourhood of Nancy, Claude de Guise--that brother of the Duke who, when a mere youth, had powerfully and valiantly contributed to deliver him, in front of Boulogne, from an overwhelming number of assailants--was taken prisoner. Thrice wounded, and with his horse killed under him, he had no choice but to yield or die. This disaster deprived Metz of a gallant defender, and plunged Guise and the whole army into deep affliction; the Duke, however, consoling himself by the resolution to make the Emperor dearly pay for his brother's ransom, and by the reflection that d'Aumale had not yielded until he was knocked down and had a cocked pistol at his throat. The sorties continued with great vigour, but at the expense of many wounded men, of whom so large a proportion died, for want of efficient medical assistance, that a rumour gained credit that the drugs were poisoned. Guise begged the King to send him Ambrose Paré with a stock of fresh medicaments, and, by the connivance of an Italian officer in the Imperialist camp, that skilful leech was introduced at midnight into the town, with the apothecary Daigue and a horse-load of medical stores. Paré was bearer of a letter from the King, thanking Guise and the other princes and nobles for all they had done and were doing to preserve his town of Metz, and assuring them he would remember and reward their services. Thus encouraged, and confident in his troops, Guise wrote to the King, with whom he found means constantly to correspond in cypher, that Metz could hold out six months without succour. On the other hand the Imperialists redoubled their efforts for success. The Emperor, who lay at Thionville, sick of the gout and expectant of triumph,