[Footnote 106: Wiggers: _Loc. cit._, p. 152.] [Footnote 107: See Pawlow: Archiv für Physiologie, 1887, p. 458. Bohr: Centralblatt für Physiologie, 1888, ii, p. 263. Meek: American Journal of Physiology, 1912, xxx, p. 173. Gray and Lunt: _Ibid._, 1914, xxxiv, p. 332.] [Footnote 108: Cannon: American Journal of Physiology, 1914, xxxiii, p. 396.] CHAPTER X THE HASTENING OF THE COAGULATION OF BLOOD IN PAIN AND GREAT EMOTION In the foregoing chapter evidence was presented that the intravenous injection of minute amounts of adrenin hastens the clotting of blood. The amounts used did not vary much above or below the amounts discharged by the adrenal glands after brief stimulation of the splanchnic nerves, as found by H. Osgood in the Harvard Laboratory, and may therefore be regarded as physiological. Since injected adrenin is capable of shortening the coagulation time, may not the increased secretion of the adrenals likewise have that effect? The answer to this question was the object of an investigation by W. L. Mendenhall and myself.[109] The blood was taken and its coagulation was recorded graphically in the manner already described. In some instances the cats were etherized, in others they were anesthetized with urethane, or were decerebrated. The splanchnic nerves always were stimulated after being cut away from connection with the spinal cord. Sometimes the nerves were isolated unilaterally in the abdomen; sometimes, in order to avoid manipulation of the abdominal viscera, they were isolated in the thorax and stimulated singly or together. A tetanizing current was used, barely perceptible on the tongue and too weak to cause by spreading any contraction of skeletal muscles. Coagulation Hastened by Splanchnic Stimulation That splanchnic stimulation accelerates the clotting of blood, and that the effects vary in different animals, are facts illustrated in the following cases: Oct. 25.--A cat was etherized and maintained in uniform ether anesthesia. After forty minutes of preliminary observation the left splanchnic nerves were stimulated in the abdomen. Following are the figures which show the effects on the coagulation time: 3.00--4 minutes .07--5.5 “ .14--4 “ .32--4.5 “ .39 to .40 Stimulation of left splanchnic. .42--5 minutes .49--5 “ .56--2 “ 4.00--1 “ .03--2.5 “ .07--2.5 “ .11--3 “ .16--2 “ .20--1.5 “ .23--4 “ .29--5.5 “ .40--5.5 “ .50--5 “