*[Footnote: If these results of emotion and pain are not “worked off” by action, it is conceivable that the excessive adrenin and sugar in the blood may have pathological effects. (Cf. Cannon: Journal of the American Medical Association, 1911, lvi, p. 742.)] The Question Whether Adrenin Normally Secreted Inhibits the Use of Sugar in the Body The only evidence opposed to the conclusion which has just been drawn is that which may be found in results recently reported by Wilenko. He injected adrenin into urethanized rabbits, usually one milligram per kilo body weight, and then found that the animals did not oxidize any part of an intravenous injection of glucose. Rabbits supplied with glucose in a similar manner, but not given adrenin, have an increased respiratory quotient. Wilenko[138] concluded, therefore, that adrenin lessens the capacity of the organism to burn carbohydrates. In a later paper he reported that adrenin, when added, with glucose, to physiological salt solution (Locke’s), and perfused through the isolated rabbit heart, notably increases the use of sugar by the heart (from 2.2-2.8 to 2.9-4.3 milligrams of glucose per gram of heart muscle per hour), but that the heart removed after the animal has received a subcutaneous injection of adrenin uses much less sugar, only 0.5-1.2 milligrams per gram per hour. From these results Wilenko[139] concludes that the glycosuria following injection of adrenin is the result of disturbance of the use of sugar--an effect which is not direct on the sugar-consuming organ, but indirect through action on some other organ. Wilenko’s conclusion fails to account readily for the disappearance of glycogen from the liver in adrenin glycosuria. Furthermore, Lusk[140] has recently reported that the subcutaneous administration of adrenin (one milligram per kilo body weight) to dogs, simultaneously with 50 grams of glucose by mouth, interferes not at all with the use of the sugar--the respiratory quotient remains for several hours at 1.0; i. e., at the figure which glucose alone would have given. In other words, Lusk’s results with dogs are directly contradictory to Wilenko’s results with rabbits. Nevertheless, Wilenko’s conclusion might be quite true for the glycosuria produced by adrenin alone (which must be excessive), and yet have no bearing whatever on the glycosuria produced physiologically by splanchnic stimulation, even though some adrenin is thereby simultaneously liberated.