In a healthy individual, where the physiological functions are performed with exactitude and regularity, the elimination of the various effete matters, the result of waste of tissue, is uniform, and easily carried off out of the system by the skin, the kidneys, lungs, and bowels. The nitrogenous components become oxidised, and urea ultimately formed, which being very soluble is freely excreted by the sudorific glands in the perspiration, and by the kidneys in the urine. The non-nitrogenous compounds are also changed by the action of oxygen into carbonic acid, which is expelled from the system by the lungs. If the natural functions are not perfectly and with regularity performed, the balance of power must of necessity be lost, and disease engendered. The system then becomes charged with uric acid, which has a strong affinity for certain bases in the human organism, and forms salts either insoluble or only slightly so, which are with difficulty eliminated either by the skin or kidneys, and hence we have the formation of calculi in the bladder, nodosities on the joints, and tophi in the ears, indicating the uric acid diathesis. The action of the Buxton nitrogenous thermal waters being solvent, stimulant, antacid, chologoge, diuretic, diaphoretic, and slightly purgative, restores the balance of power, not only by stimulating the gastric and hepatic organs to a correct performance of their normal functions, thus in conjunction with a strictly regulated diet (essential in all cases) cutting off the very source of the materies morbi, but also (when there) by eliminating it from the system by the great emunctories, viz., the skin, kidneys, lungs, and bowels. As the large proportion of invalid visitors to Buxton consist of those suffering from the uric acid or gouty diathesis, and rheumatism, and seek relief from the excruciating pains and cripplement incident to such diseases, the great attraction must of necessity be the medicinal waters, of which there are two kinds—the cold chalybeate or iron spring, and the natural thermal water. Of the former there are numerous springs in the neighbourhood of Buxton, but the only one now resorted to has been conveyed through pipes from a distance to a room adjoining the natural baths, and is used with much benefit in many forms of uterine disease as a douche. As such also it is prescribed in cases where the conjunctivæ are in a relaxed condition, consequent either upon rheumatic inflammation or local injuries. It should on no account be applied to the eyes until the inflammatory action has entirely subsided. When drunk, one tumbler (twice or thrice daily after meals) may be taken by an adult with much advantage when suffering from anæmia, chlorosis, amenorrhœa, dysmenorrhœa, diabetes connected with the gouty diathesis, chronic cystitis, or general debility.