To return to the _Late Discourse_: after some preliminary remarks, Sir KENELM records a cure which he claims to have effected by means of the Powder. It appears that JAMES HOWELL (1594-1666, afterwards historiographer royal to CHARLES II.), had, in the attempt to separate two friends engaged in a duel, received two serious wounds in the hand. To proceed in the writer's own words:--"It was my chance to be lodged hard by him; and four or five days after, as I was making myself ready, he (Mr Howell) came to my House, and prayed me to view his wounds; for I understand, said he, that you have extraordinary remedies upon such occasions, and my Surgeons apprehend some fear, that it may grow to a Gangrene, and so the hand must be cut off.... "I asked him then for any thing that had the blood upon it, so he presently sent for his Garter, wherewith his hand was first bound: and having called for a Bason of water, as if I would wash my hands; I took an handfull of Powder of Vitrol, which I had in my study, and presently dissolved it. As soon as the bloody garter was brought me, I put it within the Bason, observing in the interim what Mr _Howel_ did, who stood talking with a Gentleman in the corner of my Chamber, not regarding at all what I was doing: but he started suddenly, as if he had found some strange alteration in himself; I asked him what he ailed? I know not what ailes me, but I find that I feel no more pain, methinks that a pleasing kind of freshnesse, as it were a wet cold Napkin did spread over my hand, which hath taken away the inflammation that tormented me before; I replied, since that you feel already so good an effect of my medicament, I advise you to cast away all your Plaisters, onely keep the wound clean, and in a moderate temper 'twixt heat and cold. This was presently reported to the Duke of _Buckingham_, and a little after to the King (James I.), who were both very curious to know the issue of the businesse, which was, that after dinner I took the garter out of the water, and put it to dry before a great fire; it was scarce dry, but Mr _Howels_ servant came running (and told me), that his Master felt as much burning as ever he had done, if not more, for the heat was such, as if his hand were betwixt coales of fire: I answered, that although that had happened at present, yet he should find ease in a short time; for I knew the reason of this new accident, and I would provide accordingly, for his Master should be free from that inflammation, it may be, before he could possibly return unto him: but in case he found no ease, I wished him to come presently back again, if not he might forbear coming. Thereupon he went, and at the instant I did put again the garter into the water; thereupon he found his Master without any pain at all. To be brief, there was no sense of pain afterward: but within five or six dayes the wounds were cicatrized, and entirely healed."(1) (1) _Ibid_., pp. 7-11.