But few realize, however, that cancer is another disease which is quite as striking in its relation to faulty nitrogenous and sulphur metabolism. In my former lectures I developed this subject pretty fully and need not repeat it here, but could adduce more recent proof, did time permit. Suffice to remind you that many independent observers have recorded very important and significant errors in the nitrogen and sulphur partition in cancer, both in its early and late stages, some of which I have verified in hundreds of volumetric urinary analyses. As these errors are made to disappear by proper dietary and medicinal treatment the carcinomatous lesions have steadily improved, and in many cases have disappeared entirely, as I hope to demonstrate in a later lecture. We must, therefore, accept the fact that cancer has very close relations to the elaboration of protein in the system, and the rational deduction of this is that an overconsumption of nitrogenous food has something, if not everything, to do with the production of cancer. As yet we know little or nothing in regard to actual cancer-genesis; no one has ever demonstrated, and probably no one ever will demonstrate, the absolute beginning of the change in some normal cell or cells, in the breast or elsewhere, which eventuates in their taking on the rampant or malignant feature which we call cancer. But this change does occur, and though the exact alterations in the polarity of the cells and the disturbance of their centrosomes and nuclei, which have been described, may not be perfectly understood, there is some definite cause for their occurrence. Some have suggested the hypothesis that the mononuclear leukocyte, by conjugation with disturbed cells, gives them an abnormal reproductive power by which they eventually develop the tumor and invade other tissues. But back of all this there is still some activating cause, which is found in the fluids which bathe every tissue, namely the blood and lymph, which we shall see later are deranged in cancer. The fact that with innumerable injuries occurring everywhere and at all times cancer develops from them very rarely, should teach us something. We must conclude, therefore, that there is some constitutional condition, or rather some state of the blood, which nourishes the cells and which favors this continued malignancy—some fuel which feeds the malignant process and at the same time induces a progressive lowered vitality, ending fatally. For we have already seen in these and former lectures that the local lesion which we call cancer is but one manifestation or result of a pernicious anemia, which, if not checked, may end life in a relatively short time.