When the upper face of the tablet splits off, we speak of "capping."
To overcome this, ten per cent. of fat starch may be added to the
powder. Should "capping" still occur, the amount of fat starch might be
increased. "Capping" may also be due to the use of excessive pressure.
It may furthermore be due to die or punches being worn or damaged. When
this has occurred, the best thing to do is to get a new set of punches,
or to have the damaged one refinished by an expert mechanic, preferably
the makers of the tablet machine.
It would lead us beyond the scope of this work to give detailed
directions for making tablets of all kinds. A pharmacist who has
equipped himself with a tablet machine and has developed the ambition
to make a general line of tablets[7] may be referred to Mr. Joseph R.
Wood's book[8] on this subject.
CHAPTER VI.
THE CONSTRUCTION OF FORMULAE FOR SWEET TABLETS.
Choice of Flavor.
THERE are quite a number of medicines sufficiently free from taste
and odor to be made perfectly pleasant by the mere admixture of sugar
and of flavoring. These can, of course, be prepared with any flavor
desired. In the formulary, rose has been chosen as the flavor under
these circumstances, but any other flavor may be used instead.
Substances that have a slightly acrid taste are generally best
disguised by peppermint. For sour taste, lemon is best. Wintergreen was
chosen as the flavor for salicylates.
Substances that have a slightly bitter taste are best disguised by
"vanilla cacao sugar." For drugs that, in addition to a slightly bitter
taste, have an odor that needs disguising, "cinnamon cacao sugar" is to
be preferred.
The Subduing of Tastes.
There are quite a number of drugs that have a tendency to leave a
rather persistent disagreeable after-taste, drugs of slight solubility,
particles of which remain on the tongue longer than the sugar
does, so that their taste lingers after the taste of the sugar has
disappeared. For such drugs saccharinization solves the problem of
candy medication. The saccharin will be most efficient, as the author
has shown by repeated experiments, if it is directly incorporated with
the drug in solution rather than in dry form. Saccharinization is,
therefore, carried out in the formulary by triturating the drug with a
saturated (3 per cent.) alcoholic solution of saccharin, and permitting
the alcohol to evaporate subsequently. The drying may be expedited by
using a hot mortar. When alcohol is not permissible, as in the case
of "Alcresta" preparations (see below), dry saccharinization must be
used instead, that is, triturating the drug with saccharin, preferably
a 1 to 10 trituration. Likewise when time does not permit moist
saccharinization, triturating the substance with a somewhat larger
amount of saccharin will answer the purpose.
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