A step in the direction of rendering tablet making available for
extemporaneous preparation was made in 1909 by A. Schleimer[5] by
advocating the use of cacao butter in lieu of granulation of the
powder and subsequent drying. This brings tablets into the category
of extemporaneous preparations. All that is necessary is to add three
percent of cacao butter to the powder, and it is ready for immediate
compression in a tablet machine. Having found that cacao butter is
liable to become rancid on keeping of some tablets made with it, the
author experimented to find a substitute devoid of this tendency, and
found it in paraffin of low melting point.[6] For tablets that are
not to be kept for any length of time, cacao butter is preferable, as
it melts readily and is digestible. The amount of paraffin, however,
that enters into the composition of each tablet is so small that in
spite of its indigestibility, it seems that it could not meet with any
but theoretic objection. Either of these materials, in form of fine
shavings, is added to the extent of three to five per cent. with just
sufficient trituration to distribute fairly well. Excessive trituration
lessens the efficiency of the lubricating agent. If the tablet has a
tendency to stick to the punches, the material can be worked better if
a little talcum, say three per cent. is added to the powder by stirring
it in with a spatula rather than by trituration. This process renders
tablet making no more difficult or time-consuming than the making of
pills or capsules.
* * * * *
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