to a spot where it could be seen; elsewhere in the connective tissue I opine there are others. The patient was first seen in February, and whether sufficient time has intervened for the maturation of these parasites and the evolution of their embryos I cannot say. None, it is true, were found in the blood, but the specimen was a male, and from this it is impossible to say what the degree of maturity the embryos of any females present may be. I think the blood should be examined again, and I would suggest that if possible a similar examination should be made of the other members of the mission, and of the patients the President referred to. The locomotive habits and sensibility to cold of this parasite are particularly interesting in respect of the way in which they subserve its interests, on which they certainly have a bearing. The measurements of the _Filaria loa_ usually given, as ascertained by looking over the literature of the subject, are from 17 mm. to 70 mm. The smaller measurements are explained by the author’s case; they apply presumably to the male parasite, which in the filaridæ is almost invariably smaller than the female. One measurement given, 15 cm., is so enormous that I question the accuracy of the observation, or, if the measurement were exact, it must have referred to some other parasite than _Filaria loa_. With respect to the nature of the protrusions from the body of the parasite under the microscope, one of them is certainly the alimentary canal; the other is probably the testis ruptured in two. One must be careful in coming to a conclusion about these and similar connective-tissue parasites. There are four or five whose young inhabit the human blood; and there are others whose young appear to have a different history. Especially in West Africa do we find such parasites. There is the guinea-worm, said, however, not to be found in Old Calabar; it certainly is found in the neighbourhood; its name signifies an African origin. There is the _Filaria perstans_, the _Filaria nocturna_, and also a very minute bloodworm, _Filaria demarquayi_, the parental form of which, as of _F. perstans_, has not yet been found. There is the _Filaria volvulus_, which resembles the _Filaria loa_, in that it lives in the subcutaneous cellular tissue. Not long ago Professor Magalhães, of Rio Janeiro, described a species of filaria which he found in the left ventricle of the heart, which is also probably a new species. It follows, therefore, that before venturing on the diagnosis from specimens of parasites found in the blood or connective tissues, usually more or less mutilated, one requires to be very careful. One singular fact about the _Filaria loa_ is that it will not live in the West Indies. It has been introduced many times, but does not spread. It has been removed from the eye there from imported negro slaves, but it has not become acclimatised. In this respect it resembles very closely the _Filaria