“I do not doubt your judgment is perfectly just, and I will try to persuade myself not to publish. The whole affair is much too speculative; yet I think some such view will have to be adopted, when I call to mind such facts as the inherited effects of use and disuse, &c.” This last sentence is of great interest, and the same opinion comes out strongly in his published account of the hypothesis, viz. the view that the real facts which imperatively demand some material to pass from the body-cells to the germ-cells in order to account for their hereditary transmission are the effects of use and disuse, or the influence of surroundings--in fact, all those characters which are now called “acquired.” And it is impossible to escape the conclusion that, if acquired characters are transmissible by heredity, an hypothesis which is substantially that of pangenesis will have to be accepted. Darwin did not doubt this transmission, and he framed pangenesis mainly to account for it. Considerable doubt has of recent years been thrown upon the transmission of acquired characters, and if hereafter this doubt be justified, it will be possible to substitute for pangenesis a hypothesis like the “continuity of the germ-plasm” brought forward by Professor Weismann. A few words indicating the contrast between the two hypotheses may not be out of place. In Professor Weismann’s hypothesis the germ-plasm contained in the nucleus of the germ-cell possesses, if placed under right conditions, the power of developing into an organism. It is not, however, entirely used up during development, and the part which remains grows and is stored in the germ-cells of the offspring, and ultimately develops into the succeeding generation. Hence parent and offspring resemble each other because they are formed from the same thing. There is no real break between the generations; they are thrown up successively from a continuous line of germ-plasm. In this hypothesis the germ is the essential thing, the body a mere secondary product. It is a theory of Blastogenesis as contrasted with Pangenesis. The hereditary transmission of acquired characters, in which many still believe, is quite irreconcilable with it, and if substantiated would overthrow it altogether. On the other hand the body-cells are the essential elements of pangenesis, and the germ-cells the mere meeting-places of their representatives and quite devoid of significance on their own account. There is some sort of interruption between successive generations, as the gemmules develop into cells, which again throw off gemmules; the break, however, is bridged by the ancestral gemmules and by the life of the body-cell which intervenes between the gemmule from which it arose and that to which it gives rise.