He was the great-grandson of the Lord Alexander P.P. VI, Whose bastard Don Juan Francisco de Borja, Duke of Gandia in Spain, Prince of Teano and Tricarico, Count of Chiaramonte, Lauria, and Cerignola, Constable of Naples, and General of the Pontifical Army, had married Doña Maria de Aragona, a princess of the royal House of Aragon. After the mysterious murder of her husband at Rome in 1497, the Duchess Doña Maria married Don Enriquez de Luna, uncle and Master of the Household to the Viceroy Don Hernando of Castile, and Grand Commander of Leon, who soon left her widowed the second time. She lived at Baeza in Granada, and devoted herself to her two children, Doña Isabella, and Don Juan II de Borja, who succeeded his murdered father as Duke of Gandia and the rest. When her son married, she retired to the monastery of Poor Clares (the Second Order of the Religion of San Francesco d’Assisi) at Gandia, where she took the vows of a nun, and became Suor Maria Gabriella till her death in 1537. Her daughter, Doña Isabella, who was betrothed to the Duke of Segorbe, obtained the necessary dispensations, broke before marriage from her affianced husband; and followed the Duchess of Gandia her beloved mother to the Poor Clares, where she also took the vows as Suor Francisca de Jesus. Don Juan II married, first, Dona Francisca de Castro y Pinos; secondly, Doña Juana de Aragona, bastard of Archbishop Don Alonso de Aragona of Saragossa nephew of the Catholic King Don Hernando of Spain.[101] Fourteen children were the offspring of these marriages; DON FRANCISCO, THE SAINT: Don Alonso, Abbot of Valdigna: Don Enrico, Cardinal-Deacon of San Nereo e Sant’ Achilleo: Doña Luisa, married Don Martino de Aragona y Gurrea, Duke of Villahermosa: Don Rodrigo, Cardinal-Deacon of San Niccolo _in Carcere Tulliano_: “while still a youth” (Ciacconi) Don Pedro Luis, Viceroy of Cataluna: Don Tommaso, Archbishop of Saragossa, (in succession to Archbishop Don Juan de Aragona bastard of Archbishop Don Alonso,) and Viceroy of Aragon: Don Felipe, Knight of Montesa and Governor of Oran: Don Diego, died young: _Doña Juana, First Abbess of the Royal Monastery of Discalced Carmelites at Madrid. She died in the Odour of Sanctity_: Doña Leonor, married Don Juan de Gurrea: Doña Magdalena, married Don Hernando de Proxita, Count of Almenara: Doña Margarita, married Don Fadrique de Portugal y Cordo: * * * * * Doña Isabella, followed her grandmother Doña Maria (Suor Maria Gabriella), and her aunt Doña Isabella (Suor Francisca de Jesus) to the Poor Clares of Gandia, of which monastery she became Abbess.