We should, however, particularly attend to the investigation and discovery of the effects and operations of heat, when made to approach and retire by degrees, regularly, periodically, and by proper intervals of space and time. For this systematical inequality is in truth the daughter of heaven and mother of generation, nor can any great result be expected from a vehement, precipitate, or desultory heat. For this is not only most evident in vegetables, but in the wombs of animals also there arises a great inequality of heat, from the motion, sleep, food, and passions of the female. The same inequality prevails in those subterraneous beds where metals and fossils are perpetually forming, which renders yet more remarkable the ignorance of some of the reformed alchemists, who imagined they could attain their object by the equable heat of lamps, or the like, burning uniformly. Let this suffice concerning the operation and effects of heat; nor is it time for us to investigate them thoroughly before the forms and conformations of bodies have been further examined and brought to light. When we have determined upon our models, we may seek, apply, and arrange our instruments. IV. The fourth mode of action is by continuance, the very steward and almoner, as it were, of nature. We apply the term continuance to the abandonment of a body to itself for an observable time, guarded and protected in the mean while from all external force. For the internal motion then commences to betray and exert itself when the external and adventitious is removed. The effects of time, however, are far more delicate than those of fire. Wine, for instance, cannot be clarified by fire as it is by continuance. Nor are the ashes produced by combustion so fine as the particles dissolved or wasted by the lapse of ages. The incorporations and mixtures, which are hurried by fire, are very inferior to those obtained by continuance; and the various conformations assumed by bodies left to themselves, such as mouldiness, etc., are put a stop to by fire or a strong heat. It is not, in the mean time, unimportant to remark that there is a certain degree of violence in the motion of bodies entirely confined; for the confinement impedes the proper motion of the body. Continuance in an open vessel, therefore, is useful for separations, and in one hermetically sealed for mixtures, that in a vessel partly closed, but admitting the air, for putrefaction. But instances of the operation and effect of continuance must be collected diligently from every quarter.