Now as to treatment. It must be in the first place remembered that it is absolutely useless to worry the patient with attempts to administer medicines by the mouth, as the digestive and absorptive functions are for the time totally stopped, and it is quite as much to the purpose to put your remedies in the patient’s pocket as to force him to swallow them. To have any chance of acting, medicines must be administered by being injected beneath the skin by means of the hypodermic needle; and so powerless are all known drugs in this disease, that I should hesitate to recommend such medications to be attempted by amateur physicians. The only drug which has ever appeared to me to effect any good has been chloral hydrate dissolved in water and injected under the skin in 5-grain doses every few minutes until 30 or even 40 grains have been administered. There can be no doubt that this treatment controls the violence of the symptoms, and usually does away with the horrible suffering caused by the terrible cramps that are so common in the disease. I am even inclined to believe that a somewhat better percentage of cases recover under the treatment, though this is doubtful. Failing this, massage and frictions with the hands do much to relieve the cramps, and in the cold stage, every care should be taken to maintain the heat of the body by covering the patient with blankets and placing around him bricks heated in the fire and wrapped round with strips of wet blanket. During the reaction that follows on the cold stage, in favourable cases, attempts should be made to stimulate the kidneys by the application of mustard plasters to the loins. To attempt to give food during the acute stage is obviously worse than useless, but there is no harm in letting the patient suck small lumps of ice to assuage the terrible thirst of the disease. In the stage of collapse, stimulants naturally suggest themselves, but are seldom of any use when given internally. A few drops of ether inhaled from a handkerchief is, if available, perhaps the best method of stimulation, but the weakened kidneys have quite enough to do without having to deal with alcohol, so that it should be but sparingly resorted to, if at all. When the patient shows such signs of recovery that it appears likely that food can be tolerated, small quantities only of easily digestible food, such as milk, rendered mucilaginous by the addition of a little arrowroot, Brand’s extract, &c., should be given, but it can easily be understood that after so severe a shock to the digestive system, the greatest care will have to be exercised in the feeding of the patient. Finally, it should not be forgotten that all the discharges of the patient are virulently infective, and that they and everything soiled by them should at once be disinfected. When the supply of disinfectants is limited, a good plan is to place in the bed-pan and basins used a sufficiency of