COCA IN COMMERCE 46 Report by Hon. R. Gibbs, U.S. Minister—Mode of importation into Europe. CHAPTER XI. USE OF COCA AS A RESTORATIVE 48 Resembles Tea in its action—Apt to cause insomnia—Taste, and effects of its use in infusion. CHAPTER XII. PHARMACEUTICAL PREPARATIONS 50 Elixir—Extractum Liquidum—Extractum—Infusum—Pastillus Extracti—Vinum—Coca Wine. CHAPTER XIII. MEDICAL USES AND REFERENCES 52 Tonic effects—Relief of fatigue—Relief of various diseases and symptoms—Coca-craving—Topical effects—Abstracts from the medical journals. CHAPTER XIV. COCAINE AND ITS SALTS 54 Cocaina—Chemical constitution—Mode of preparation—Tests and solubilities—Bougies—Ceratum—Collodium—Emplastrum—Oleatum Oleum cum Cocainâ—Suppositories—Pessaries—Tabellæ—Unguentum—Vaselinum—Cocainæ Citras—Cocainæ Hydrobromas—Cocainæ Hydrochloras—Buginaria—Injectio Hypodermica—Lamellæ—Liquor—Pastillus—Pilula—Tabloids—Trochisci—Cocainæ Salicylas—Dentifricium. CHAPTER XV. USES OF COCAINE 61 Local anæsthetic effects—Mydriatic effects, surgical uses—Toxic effects, its mode of action—Diseases for which it is useful. CHAPTER XVI. MEDICAL NOTES AND REFERENCES 69 [Illustration: Decoration] INTRODUCTION. The medical interest which has centred in Cocaine as a local anæsthetic during the last few years, has gradually become diffused as “public opinion,” the more so, of late, as it has been recommended as a remedy for sea-sickness, from which Britons all more or less suffer on leaving our seagirt home; otherwise, internally, Cocaine has been but little used compared with its probably extended use in the future, when its effects are better known. This now important alkaloid is obtained from the leaves of _Erythroxylon Coca_, Lamarck, a shrub cultivated on the eastern slopes and plateaux of the Andes, chiefly in Bolivia and Peru, but also in the Argentine Republic, Ecuador, United States of Colombia, and Central America, as far north as San Salvador, and latterly in Java, Ceylon, and some parts of British India. COCA AND COCAINE. CHAPTER I. EARLY HISTORY. The earliest accounts extant of Coca are contained in the writings of the historians who treat of the Spanish conquests in South America in the sixteenth century, and of Spanish travellers and Jesuit missionaries who followed in their wake.